JNPC_【DOC精选】.docx

Research ArticleFeasibility and efficiency of concurrent chemo-radiotherapy for nasopharyngeal carcinoma patientsImene Essaidi, Dalenda Hentati, Chiraz Nasr, Lotfi Kochbati, Mongi MaalejRadio-Oncology Department Salah Azaiz Cancer Institute, boulevard du 9-Avril, 1006 Tunis, TunisiaCitation: Essaidi I, Hentati D, Nasr C, Kochbati L, Maalej M.Feasibility and efficiency of concurrent chemo-radiotherapy for nasopharyngeal carcinoma patients. J Nasopharyng Carcinoma, 2015, 1(21): e21. doi:10.15383/jnpc.21.Competing interests:The authors have declared that no competing interests exist.Conflict of interest: None.Copyright:2014 By the Editorial Department of Journal of Nasopharyngeal Carcinoma. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Abstract:Purpose:To evaluate the feasibility and efficiency ofconcurrent chemo-radiotherapy (CCRT) in nasopharyngeal carcinoma(NPC) patients.Patients and Methods: We reviewed data of 33non-metastatic NPC patients who had been treated with CCRT between January 2004 and December 2006.The Median age of patients was 41 year-old and the male/female ratio was 3.According to the 2002 TNM staging system, T3-T4 locally advanced tumors and N2-N3 nodal status rates were 67% and 46%, respectively. All patients had undifferentiated carcinoma and received conventional fractionated 2D conventional radiotherapy (RT)with a total dose of 70-74 Gyandconcurrent weekly intravenous cisplatin (40 mg/m2).Results:The acute toxicities were all manageable. Grade 3-4 mucositis and skin reaction were seen in 6 patients (18%). RT interruption for a week occurred in 1 patient because of a Grade 3 dysphagia. All patients finished their planned RT. Four patients (12%) refused to complete the concurrent chemotherapy (CT) and 5 other patients (15%) did not receive the planned cycles of