三种血液净化法在尿毒症患者毒素清除中的效果观察.docVIP

三种血液净化法在尿毒症患者毒素清除中的效果观察 　　[摘要] 目的 探讨三种不同血液净化方法在尿毒症患者毒素清除中的应用效果。 方法 本院2013年1～12月接诊的尿毒症患者中选取57例，随机分为血液透析组（HD组）、血液透析滤过组（HDF组）、血液透析联合血液灌流组（HD+HP组），比较3组治疗前后血清磷、β2微球蛋白（β2-MG）、尿素氮（BUN）、全段甲状旁腺激素（iPTH）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、血清脂蛋白（a）[LP（a）]、C反应蛋白（CRP）、载脂蛋白A1（ApoA1）、载脂蛋白B100（ApoB100）、脂蛋白酯酶（LPL）、肿瘤坏死因子-α（TNF-α）指标的变化。 结果 治疗前各项指标差异无统计学意义（P0.05）；治疗后，3组患者各项指标均有改善（P0.05），且HD+HP组的改善效果优于其他两组（P0.05）。结论 血液透析联合血液灌流治疗尿毒症，能够取得理想的治疗效果，可快速排除患者体内的毒素，对改善循环有积极作用。 　　[关键词] 尿毒症；血液净化；毒素清除 　　[中图分类号] R692.5[文献标识码] A[文章编号] 1674-4721（2014）06（a）-0025-03 　　 　　Effect observation of three kinds of blood purification methods in toxin elimination of patients with uremia 　　WU Gang1 WANG Fang2 PAN Miao2 　　1.People′s Hospital of Zhushan County in Shiyan City of Hubei Province,Zhushan 442200;China;2.Department of Nephrology,Ningde Hospital of Fujian Province,Ningde 352100,China 　　[Abstract] Objective To compare the effects of three kinds of blood purification methods in toxin elimination of patients with uremia. Methods 57 cases of patients with uremic in our hospital from January to December 2013 were selected and randomly divided into hemodialysis group (HD group),hemodialysis filtration group (HDF group),hemodialysis and hemoperfusion group (HD+HP group),the serum phosphorus,β2-microglobulin (β2-MG),urea nitrogen (BUN),intact parathyroid hormone (iPTH),low-density lipoprotein (LDL),high density lipoprotein (HDL),serum lipoprotein (a) [LP (a)],C reactive protein (CRP),apolipoprotein A1 (ApoA1),apolipoprotein B100 (ApoB100),lipoprotein lipase (LPL),tumor necrosis factor-α (TNF-α) in the three groups before and after treatment were observed. Results Before treatment,the indicators of three groups had no significant different (P0.05);After treatment,the indicators of three group were all improved (P0.05),and the improvement of HD+HP group was better than that of the other two groups respectively (P0.05). Conclusion Effect of HD+HP in treatment of uremia is ideal,and has positive effect for toxin eli