同型半胱氨酸与原发性高血压发病的关系.docVIP

同型半胱氨酸与原发性高血压发病的关系 　　doi：10.3969/j.issn.1007-614x.2014.14.53 　　摘 要 目的：探讨血清同型半胱氨酸（Hcy）水平与原发性高血压的关系，为临床检测、早期诊断EH提供资料和方法。方法：共收集病例376例，分为两组。原发性高血压组156例，均为2012年收治的原发性高血压患者；对照组220例，均为2012年健康体检者。376例受检者均于清晨安静平卧状态下抽空腹静脉血4ml，2小时内离心得血清标本，随即用奥林巴斯AU-680全自动生化分析仪测定血清标本的Hcy值。结果：原发性高血压组平均Hcy值（20.36±2.25）μmol/L。对照组平均Hcy值（12.13±1.22）μmol/L。两组平均Hcy值比较差异有统计学意义（P0.01）。结论：临床上尽早检测Hcy，及时发现并治疗高同型半胱氨酸血症，有助于高血压病的早期干预和治疗。 　　关键词 同型半胱氨酸 原发性高血压 治疗 　　Investigate the relationship between homocysteine and the incidence of essential hypertension 　　Du Jianmei 　　Cardiovascular and Encephalopathy Department in Lanzhou Chinese Medicine Hospital of Gansu Province，730050 　　Abstract Objective：To investigate relationship between serum homocysteine（Hcy）level and essential hypertension，to provide information and methods for clinical monitoring and early diagnosis of essential hypertension（EH）.Methods：376 patients were divided into two groups，essential hypertensive group with 156 EH patients who were admitted in 2012，and control group with 220 healthy persons in 2012.Pumping 4ml fasting blood in 376 cases subjects lying quiet in the early morning state，and get serum specimens through centrifugal within two hours，then measured Hcy values with Olympus AU-680 automatic biochemical analyzer.Results： The mean Hcy value of essential hypertension group was 20.36±2.25μmol/L. The mean Hcy values of control group was 12.13±1.22μmol/L.The mean Hcy values ？？are significantly different（P0.01）.Conclusion：Clinically detection HCY early，timely detection and treatment of hyperhomocysteinemia，have an important role in early intervention and treatment for high blood pressure. 　　Key words Homocysteine；essential hypertension；Treatment 　　高血压作为一种常见的心血管疾病，对人类健康构成了严重威胁，如果能够进行早期诊断，对高血压病防治将产生重大意义[1]。同型半胱氨酸是蛋氨酸循环正常代谢过程中产生的一种含硫氨基酸，是机体许多需甲基化反应以及能量代谢的重要中间产物。众多的研究结果显示，高同型半胱氨酸血症与心脑血管疾病发生存在着密切的联系[2]。本文通过测定血清同型半胱氨酸（Hcy）水平，探讨其与原发性高血压（EH）的关系，为临床检测、早期诊断提供资料和方法。 　　资料与方法 　　共收集病例376例，分为两组。原发性高血压组156例（41.49%），男128例，女28例，年龄30～65岁，平均（36.12