TCellMaturationActivationand.pptVIP

no signal 2 Clonal Expansion versus Clonal Anergy CD28 no signal 2 The Resulting Anergic T Cells Cannot Respond to Normal APCs signal 2 signal 1 signal 2 signal 1 Superantigen-mediated Crosslinkage of T-cell Receptor and Class II MHC Molecules various bacterial Mls Ags encoded by mouse exotoxins mammary tumor virus * Chapter 10 T-Cell Maturation, Activation, and Differentiation 本章大綱: T-Cell Maturation and the Thymus Thymic Selection of the T-Cell Repertoire TH-Cell Activation T-Cell Differentiation Cell Death and T-Cell populations Peripheral gd T-Cells T-Cell Maturation and the Thymus The Human Lymphoid System The Normal Rat Thymus The Thymus stromal cells: maturation Two-step Selection Process of Thymocytes Positive Selection: permits the survival of only those T cells whose TCRs recognize self-MHC molecules. Negative Selection: eliminates T cells that react too strongly with self-MHC or with self-MHC plus self-peptides. Thymic stromal cells, which express high levels of class I and class II MHC molecules, play a role in this process. - Any developing thymocytes that are unable to recognize self-MHC molecules or that do have a high affinity for self-Ag plus self-MHC (or self-MHC alone) are eliminated by programmed cell death. Thus, only those cells whose receptors recognize a self- MHC molecules plus foreign Ag are allowed to mature. - An estimated 95%--99% of all thymocyte progeny undergo programmed cell death within the thymus without ever maturing. Various features used to characterize the pathway of T-cell development in the thymus TCR-gene rearrangement Activity of genes, such as RAG-1 and RAG-2, that are involved in TCR rearrangement 3. Display of surface Ags specific for T-cell differentiation. TCR CD4 CD8 Most of the immune th