5项特异性生化指标联合肝功能分级用于肝癌诊断中的准确性及敏感性分析.doc

5项特异性生化指标联合肝功能分级用于肝癌诊断中的准确性 及敏感性分析 Accuracy and sensitivity analysis of 5 specific biochemical indexes combined with liver function classification in the diagnosis of hepatocellular carcinoma 摘要 目的 对5项特异性生化指标联合肝功能分级用于肝癌诊断中的准确性及敏感性予以分析，为其临床应用提供数据支持。 方法 选取2015年6月-2016年6月间我院诊疗的112例肝癌疑似患者为研究对象，采用随机数字表法将其分为观察和对照组，观察组根据AFP、AFU、γ-GT、DR-70TM、TNF-α5项特异性生化指标及肝功能分级结果进行诊断；对照组按临床症状结合CT检查结果进行诊断。并以其病理诊断结果为标准对两组诊断的准确性和敏感性等数据进行评价及组间比较。 结果 两研究组性别、年龄、病程及BMI等基线资料组间无显著差异性（P＞0.05），具有可比性；两研究组的诊断准确率分别为91.2%和76.4%，观察组显著优于对照组（P＜0.05）；两研究组敏感性分别为63.2%和54.5%，观察组显著低于对照组（P＜0.05）。 结论 AFP、AFU、γ-GT、DR-70TM、TNF-α特异性生化指标联合肝功能分级用于肝癌诊断中具有准确性高及敏感性高等优势，具有应用及推广价值。 关键词：5项特异性生化指标；肝功能分级；肝癌；病理诊断；准确性；敏感性 Abstract Objective To analyze the accuracy and sensitivity of 5 specific biochemical indexes combined with liver function classification in the diagnosis of hepatocellular carcinoma, and to provide data support for clinical application. Methods From June 2015 -2016 year in June in our hospital 112 cases of suspected liver cancer patients as the research object, randomly divided into observation group and control group, the observation group according to the AFP、AFU、γ-GT、DR-70TM、TNF-αbiochemical indexes and liver function classification results for diagnosis; control group according to the clinical symptoms combined with CT test results for diagnosis. And the diagnostic accuracy and sensitivity of the two groups were evaluated by the criteria of pathological diagnosis. Results Of two groups of gender, age and course of disease and BMI baseline data between the groups had no significant difference (P 0.05), comparable; the diagnostic accuracy of the two study groups were 91.2% and 76.4%, the observation group was significantly better than the control group (P 0.05); sensitivity group were 63.2% and two of 54.5%, the observation group was significantly lower than the control group (P 0.05). Conclusion AFP、AFU、γ-GT、DR-70TM、TNF-αbiochemical indexes combined with liver function classification in the diagn