离子通道与心律失常1.pptVIP

Five phases of ventricular AP Action potentials of different autorhythmic cells Action potentials of autorhythmic cells 窦房结P细胞 舒张去极化由外向电流IK的衰减和内向电流If，ICa-T的增加引起。 0期去极由ICa-L引起，没有1期和2期，3期由IK引起，有4期自动去极化过程。 SA AV PF SA node AP shows a deeper slope of pacemaker potential, and has the fastest pacemaker rates of ~90-100 beats/ min and so is the normal pacemaker. The AV node is the next fastest (~40-60 beats/min). In normal conditions helps spread AP to ventricles from right atrium Purkinje fibers have 15-30 beats/ min. Under normal conditions helps spread AP to rest of ventricles ICa INa ICa *