分子生物学28350课件.pptVIP

Effect of DNA Looping on DNase Susceptibility Operators separated by Integral number of double-helical turns can loop out DNA to allow cooperative binding Nonintegral number of turns requires proteins to bind to opposite faces of DNA and no cooperative binding When λ operators are separated by an integral number of helical turns, the DNA in between can loop out to allow cooperative binding. When the operators are separated by a nonintegral number of helical turns, the proteins have to bind to opposite faces of the DNA double helix, so no cooperative binding can take place. SUMMARY 3) Enh