Sox9在临床常见疾病中的研究进展.PDFVIP

23808 2 中华临床医师杂志( 电子版)2016 年12 月第10 卷第24 期 Chin J Clinicians(Electronic Edition),December 15,2016,Vol.10,No.24 2综述2 Sox9 在临床常见疾病中的研究进展 1 1 1 1,2 1,2 冯爽 隋晓栋 李丹 张莉 杨志诚 【摘要】 Sox9 （SRY-related HMG-box gene 9 ）基因是一种与胚胎早期发育相关的重要基因， 是Sox 转录因子家族的重要成员之一，其在胚胎早期的原始生殖嵴细胞中表达，在软骨的形成过程 中起重要作用，并能够促使睾丸支持细胞分化。随着对Sox9 研究的不断深入，其与临床疾病的关系 也在不断地被发现，其在临床领域中的应用也将日渐深入，为临床各种疾病的诊疗提供新的思路。 【关键词】 肿瘤； 糖尿病； Sox 基因； Sox9 基因 1 1 1 Research development of Sox9 in clinical common diseases Feng Shuang , Sui Xiaodong , Li Dan , Zhang Li1,2, Yang Zhicheng1,2. 1School of Stomatology, Binzhou Medical University, Yantai 264003, China; 2Department of Stomatology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264100, China Corresponding author: Yang Zhicheng, Email: 【Abstract 】 The Sox9 gene is a kind of important genes associated with early embryonic development and one of the important members of the Sox transcription factors family, it is expressed in the original genital ridge cell of the early embryonic, and plays an important role in the process of the formation of cartilage, and could lead to testicular sertoli cells differentiation. With the deepening of research on Sox9, its relationship with clinical diseases is also being discovered, its application in the field of clinical will be increasingly in-depth and providing a new method for clinical diagnosis and treatment of various diseases. 【Key words 】 Neoplasms; Diabetes mellitus; Sox gene; Sox9 gene 一、Sox 基因家族? Sox 基因广泛存在于动物界中，迄今在鱼类、 1. Sox 基因的一般特点：Sox 基因家族是人们