Neural Network Analysis of Flow Cytometry Immunophenotype Data流式细胞仪检测细胞的免疫表型数据的神经网络分析.pptVIP

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Neural Network Analysis of Flow Cytometry Immunophenotype Data流式细胞仪检测细胞的免疫表型数据的神经网络分析.ppt

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Neural Network Analysis of Flow Cytometry Immunophenotype Data流式细胞仪检测细胞的免疫表型数据的神经网络分析

Neural Network Analysis of Flow Cytometry Immunophenotype Data Mehrshad Mokhtaran M.D. Acute Leukemia Definition Malignant Event Replace the bone marrow with blast Clinical Complication: Anemia, Infection, Bleeding Rapidly fatal With appropriate therapy, the natural history can be markedly altered, and many patient can be cured. Acute Leukemia Etiology: Radiation Oncogenic Viruses Genetic and Congenital Factors Chemical and Drugs Acute Leukemia Incidence: Annual new case (All Leukemia): 8 to 10 per 100,000. Remained static over the past three decades. ALL:11% CLL:29% AML:46% CML:14% 3% of all cancer in United States ALL is most common cancer in children(15y) ALL is second cause of death in children(15y) ALL has tow maximum incidence per age AML gradually increases with age Half of AML cases occur in patients younger than 50 y Acute Leukemia Pathophysiology: Acute Leukemia Classification Morphology Cytochemistry Cell-surface markers Cytoplasmic markers Cytogenetics Oncogene expression Acute Leukemia Must important Distinction is between: AML ALL Clinical behavior, prognosis, response to therapy AML (FAB) M0, M1, M2, M3: Increasing degree of differentiation M4, M5: Monocytic lineage M6: Erytroid cell linage M7: Acute Megakaryocytic Leukemia ALL (FAB) L1 L2 L3 Acute Leukemia Cell-surface Markers: AML Normal immature myeloid cells and blast cells from most patient with AML: CD13, CD14, CD33, CD34 M6, M7: Antigens restricted to red cell and platelet lineage AML may express: HLA-DR antigen 10-20%: B- or T-cell lineage ALL 60% of ALL: CALLA(CD10) (early pre-B-cell differentiation state) Pre-B-cell ALL: 20% CALLA-positive that have intracytoplasmic immunoglobulin B-cell ALL(5%): Immunoglobulin on cell surface T-cell ALL(20%): CD5, CD3 or CD2 (normal early T-cell) Null cell ALL (15%): Fail to express CALLA, B- , T-cell markers 25% of ALL: Myeloid antigens Acute Leukemia Cytogenetics and Molecular biology: Acute Leukemia Clinical Manifestations: Decreaseing norm