2种中西结合方案治疗普通型手足口病的成本―效果分析.docVIP

2种中西结合方案治疗普通型手足口病的成本―效果分析 　　[摘要]目的 探讨2种中西结合方案治疗普通型手足口病的成本及临床效果。方法 选择2015年5～8月我院收治的100例普通型手足口病患儿作为研究对象，采用随机数字表法分为A组和B组，各50例。A组采用喜炎平+利巴韦林治疗，B组采用小儿牛黄清心散+单磷酸阿糖腺苷治疗，比较两组患者治疗效果、症状体征改善及不良反应情况，并对2种疗法作经济性分析。结果 A组总有效率（94%）显著高于B组（82%）（P0.05）。A组患儿住院时间和医疗费用均显著少于B组（P0.05）。结论 普通型手足口病采用喜炎平+利巴韦林中西结合方案治疗临床效果可靠，具有起效快、疗程短、不良反应少等优势，且成本低廉，经济性较好。 　　[关键词]小儿手足口病；单磷酸阿糖腺苷；成本-效果分析；小儿牛黄清心散；喜炎平；利巴韦林 　　[中图分类号] R965 [文献标识码] A [文章编号] 1674-4721（2016）09（b）-0133-04 　　[Abstract]Objective To explore the cost and clinical effect of 2 kinds of Chinese and Western combined therapy for common type hand foot and mouth disease.Methods 100 cases of children with common hand foot and mouth disease in our hospital from May to August 2015 were selected as research object and divided into group A and group B by random number table，each group was 50 cases.Patients in group A were treated with Xiyanping and Ribavirin，while in group B with Infantile Niuhuang Qingxinsan+Vidarabine Monophosphate，treatment effect，improvement of symptoms and signs and adverse reaction between two groups were compared，the two kinds of therapies were analysed for economic.Results Total effective rate of group A with 94% was significantly higher than 82% of group B，the difference was statistically significant （P0.05）.The hospital stays and medical expenses of group A were significantly less than that of group B （P0.05）.Conclusion Clinical effect of Xiyanping and Ribavirin combination of Chinese and Western in treatment of common type of hand foot and mouth disease is reliable，which has the advantages of quick effect，short course of treatment，less adverse reaction and so on，and low cost，economy is better. 　　[Key words]Children with hand foot and mouth disease；Vidarabine Monophosphate；Cost-effect analysis；Infantile Niuhuang Qingxinsan；Xiyanping；Ribavirin 　　手足口病是幼儿常见的传染性疾病，较容易出现大规模的暴发性感染疫情，临床治疗难度较大。该病主要临床表现为发热，口腔黏膜、手足部位出现丘疹、疱疹、溃疡等，严重患儿可能出现脑炎、循环衰竭、肺气肿等并发症，容易导致患儿死亡[1]。手足口病是由病毒感染引起的发疹性传染病，西药临床治疗尚无特效抗病毒药物，临床治疗效果有限。近年来，较多中医药文献研究报道，较多中药制剂在