人参总皂甙对失眠症患者的交感神经皮肤反应影响的临床研究.docVIP

人参总皂甙对失眠症患者的交感神经皮肤反应影响的临床研究 　　【摘要】 目的：探讨人参总皂甙对失眠症患者的交感神经皮肤反应（SSR）的影响。方法：将60例失眠症患者分为两组，单纯人参总皂甙治疗组（R组，30例），人参总皂甙治疗+基础用药组（RJ组，30例），同时选择30例性别、年龄相匹配的健康成人为对照组。对两组患者在治疗前后以及对照组分别采用电刺激法进行SSR检查，记录各组SSR的异常率和SSR的潜伏期及波幅，并进行相关统计分析。结果：60例失眠症患者在治疗前SSR总的异常率为90.0%，治疗30 d后SSR总的异常率为53.3%，与治疗前比较SSR潜伏期和波幅异常率均得到明显改善，差异均有统计学意义（P0.05）。结论：人参总皂甙能明显改善失眠症患者SSR，改善患者的自主神经功能。 　　【关键词】 失眠； 交感神经皮肤反应； 人参总皂甙 　　中图分类号 R749.71 文献标识码 A 文章编号 1674-6805（2016）10-0004-03 　　【Abstract】 Objective：To study the effect of Total Saponins of Panax Ginseng on sympathetic skin response in patients with insomnia.Method：60 patients with insomnia were divided into two groups，the treatment group of Total Saponins of Panax Ginseng（R group，30 cases），the treatment group of Total Saponins of Panax Ginseng and basic medication group（RJ group，30 cases）.At the same time，30 healthy adults were selected as the control group.Two groups of patients before and after treatment as well as the control group were treated by electric stimulation SSR examination.The abnormality rate of SSR and the latency and amplitude of SSR were recorded and analyzed statistically.Result：The SSR total abnormal rate of 60 insomnia patients before treatment was 90.0%，30 days after treatment，the SSR total abnormal rate of 60 cases of insomnia was 53.3%，compared with before treatment，the abnormal rate of SSR latency and amplitude were significantly improved，the differences were statistically significant（P0.05）.Conclusion：The Total Saponins of Panax Ginseng can significantly improve the patients with SSR，improve the patients’ autonomic nerve function. 　　【Key words】 Insomnia； Sympathetic skin response； Total Saponins of Panax Ginseng 　　First-author’s address：Tianjin University of Traditional Chinese Medicine，Tianjin 300193，China 　　doi：10.14033/j.cnki.cfmr.2016.10.002 　　失眠症是目前最常见的睡眠障碍之一，严重影响人类的睡眠质量及身心健康。失眠患者常伴有头痛、头晕和全身不适等多种躯体形式障碍和自主神经功能障碍。交感神经皮肤反应（sympathetic skin response，SSR）是人体接受刺激后出现的皮肤-交感神经泌汗体表电压变化的反应，是客观反映自主神经功能的电生理指标，20世纪80年代开始应用于临床。由于该方法无创、简便、敏