结肠癌血清IL―8和VEGF的表达水平.docVIP

结肠癌血清IL―8和VEGF的表达水平 　　【摘要】目的：探究结肠癌患者血清白介素-8（IL-8）和血管内皮生长因子（VEGF）的表达水平。方法：选取76例确诊结肠癌患者作为研究对象设为观察组，另选同期于我院健康体检的76例健康人作为对照组。对健康者及结肠癌患者术前、术后血清IL-8和VEGF水平用酶联免疫吸附法（ELISE法）进行检测，比较组间差异，分析结肠癌患者血清IL-8和VEGF的表达水平。结果：观察组结肠癌患者血清IL-8和VEGF水平明显高于对照组健康人群，同为患癌人群中结肠癌Dukes C、D期血清IL-8和VEGF水平亦明显高于A、B期患者，组间差异有统计学意义（P0.05）；行肿瘤根治术后患者血清IL-8和VEGF水平与术前相比明显下降（P0.05），但仍明显较健康者高，差异有统计学意义（P0.05）。结论：血清IL-8和VEGF表达水平与结肠癌的病情进展关系密切，对疾病的病情判断和预后评估价值明确。 　　【关键词】结肠癌；白介素-8；血管内皮生长因子；表达 　　【中图分类号】R446.11 【文献标志码】 A 【文章编号】1007-8517（2016）08-0063-02 　　Abstract：Objective To investigate the levels of interleukin-8（IL-8） and Vascular Endothelial Growth Factor（VEGF） expressions in serum of colon cancer patients. Methods Selected 76 colon cancer patients as the observed group， and 76 healthy people made physical examination as the controlled group. Detected the levels of IL-8 and VEGFin serum of healthy people，preoperative and postoperativecolon cancer patients by enzyme-linked immunosorbent assay （ELISA）. Compared the difference between the data sets， and analyzed the levels of IL-8 and VEGF expressions in serum of colon cancer patients.Results The levels of IL-8 and VEGF expressions in serum of colon cancer patients were clearly higher than these of the healthy ones， and the levels of the patients diagnosed as Dukes C， D in the observed group were higher than these of Dukes A， B， with significant difference （P0.05）. Compared with levels of patients before surgery， the levels after surgery declined greatly（P0.05）， but still higher than these of healthy people，with significant difference （P0.05）.Conclusion The levels of IL-8 and VEGF expressions in serum are germane to the progression of colon cancer， and are valuable for the judgment and prognosis of the disease condition assessment. 　　Keywords：IL-8；VEGF；Expressions；Colon Cancer； 　　结肠癌是临床常见的胃肠道恶性肿瘤，多以中老年人群高发，近年来发病率及死亡率逐渐升高，青年患者的数量也不断增多[1]。结肠癌的早期症状较轻而易误诊或漏诊，就医时多已为晚期，且常发生癌细胞扩散和转移，可经过直接浸润、血行转移、淋巴结转移及种植转移，严重影响患者的生命健康和生活质量[2]。有研究发现，IL-8和VEGF与肿瘤的发生和疾病的发展有着密切的关联，为观察血清