胺碘酮与利多卡因治疗急性心肌梗死合并室性心律失常的效果比较.docVIP

胺碘酮与利多卡因治疗急性心肌梗死合并室性心律失常的效果比较 　　[摘要] 目的 分析胺碘酮与利多卡因对急性心肌梗死合并室性心律失常患者的疗效。 方法 选取2013年3月～2015年3月在我院进行治疗的120例急性心肌梗死合并室性心律失常的患者作为研究对象，采用随机数字表法将其分为胺碘酮组和利多卡因组。利多卡因组患者接受利多卡因静脉注射治疗；胺碘酮组患者接受胺碘酮治疗。比较两组患者经过不同药物治疗后的临床疗效及不良反应发生情况。 结果 治疗后，胺碘酮组临床总有效率（93.33%）显著高于利多卡因组（68.33%），差异有统计学意义（P0.05）。 结论 对急性心肌梗死合并室性心律失常患者分别给予胺碘酮及利多卡因进行治疗后，胺碘酮临床疗效显著，不良反应少。 　　[关键词] 胺碘酮；利多卡因；急性心肌梗死；室性心律失常 　　[中图分类号] R542.2+2 [文献标识码] A [文章编号] 1674-4721（2016）05（c）-0075-03 　　Comparison efficacy of amiodarone and lidocaine in the treatment of acute myocardial infarction combined with ventricular arrhythmia 　　LI Xian-liang JIANG Xian-yan CUI Mei-ping JIANG Wen-bin GUO Xiao 　　Heart Center，Fuwai Cardiovascular Disease Hospital of Qingdao City，Qingdao 266034，China 　　[Abstract] Objective To analyze the efficacy of amiodarone and lidocaine in patients with acute myocardial infarction （AMI） combined with ventricular arrhythmia. Methods From March 2013 to March 2015，120 patients with AMI and ventricular arrhythmia treated in our hospital were selected as research objects.They were divided by a random number table.In lidocaine group，lidocaine via intravenous injection was used，while in amiodarone group，patients were treated with amiodarone.The clinical effect and occurrence of adverse reactions after different medications between the two groups were compared. Results After different medications，the total effective rate in the amiodarone group was 93.33%，much higher than that in the lidocaine group accounting for 68.33%，with a statistical difference（P0.05）. Conclusion For patients with AMI and ventricular arrhythmia，amiodarone and lidocaine are provided separately for treatment，and clinical efficacy is remarkable after using amiodarone with few adverse reactions. 　　[Key words] Amiodarone；Lidocaine；Acute myocardial infarction；Ventricular arrhythmia 　　急性心肌梗死患者极易并发室性心律失常，其高发生率导致患者病情危险性显著增高。过去临床上对急性心肌梗死合并心律失常患者的治疗多采用利多卡因静脉注射。利多卡因有明显的首过效应，药效受心排血量和肝血流量的影响较大，所以采用利多卡因治疗的临床疗效较低[1-2]。胺碘酮作为Ⅲ类抗心律失常药，具有轻度非竞争性的α及β肾上腺素受体阻滞作用，其通过