雌二醇、孕酮及β―人绒毛膜促性腺激素水平变化对早期先兆性流产的预测价值分析.docVIP

雌二醇、孕酮及β―人绒毛膜促性腺激素水平变化对早期先兆性流产的预测价值分析 　　【摘要】目的：研究雌二醇（E2）、孕酮（P）及β-人绒毛膜促性腺激素（β-HCG）水平变化对早期先兆性流产的预测价值。方法：选择2014年12月至2015年10月在我院就诊的早期妊娠女性130例，按照临床检查情况分为A组及B组，A组均为早期先兆性流产妊娠女性，B组均为早期输卵管妊娠女性；再选择正常早孕孕妇65例纳入C组，三组一般资料比较无统计学意义（P0.05）。三组均于入院后次日及第8d行 E2、P、β-HCG检测，比较三组检测结果及诊断符合率。结果：C组E2、P、β-HCG检测值均显著高于A组、B组（P均0.05），β-HCG检测值较入院次日显著升高（P0.05）；8d后C组E2、P、β-HCG检测值均较入院次日显著升高（P均0.05）。联合诊断符合率（95.00%）远高于E2（83.33%）、P（81.67%）、β-HCG（78.33%），P均0.05；结论：E2、P、β-HCG联合检测对先兆流产较E2、P、β-HCG单独检测具有更高的应用价值。 　　【关键词】雌二醇；孕酮；β-人绒毛膜促性腺激素；早期先兆性流产；预测价值 　　【Abstract】Objectives： To study the effects of estradiol （E2）， progesterone （P） and human chorionic gonadotropin （β-HCG） value level change in the prediction of early threatened abortion. Methods： 130 early pregnant women in our hospital from Dec. 2014 to Oct. 2015 were selected and， according to the clinical examination， were divided into group A and group B. Croup A were pregnant women of early threatened abortion and group B were early tubal pregnant women. Another 65 normal pregnant women were enrolled as group C. The general data of the three groups had no statistical significance （P 0.05）. All the three groups received E2， P， 8d and β-HCG detection on the 2nd and 8th day after being admitted to hospital， to compare the coincidence rate of detection and diagnosis results. Results： The E2， P， β-HCG detection values in group C were significantly higher than group A and group B （P 0.05）， and β-HCG detection value increased significantly （P 0.05）； the E2， P ，β-HCG value of group C were significantly increased （P 0.05）. The diagnosis coincidence rate （95%） was much higher than that of E2 （83.33%）， P （81.67%）， HCG （78.33%）， P0.05. Conclusion： The combined detection of E2， P andβ-HCG has higher application value for threatened abortion than the detection alone. 　　【Key words】Estradiol； Progesterone； Human chorionic gonadotropin； Early Threatened abortion； Predictive value 　　【中图分类号】R169.42【文献标志码】A 　　先兆性流产为妊娠期最常见的疾病之一，其发病率约为所有妊娠期女性的10%～15%[1]。研究发现，早期发现并采取有效措