肿瘤细胞能量代谢中潜在的治疗靶点.pdfVIP

生命的化学, 2015, 35(1): 45-50 林碧云, 等. 肿瘤细胞能量代谢中潜在的治疗靶点 doi: 10.13488/j.smhx 45 · 肿瘤细胞能量代谢中潜在的治疗靶点 林碧云，黎旭，张海涛* (广东医学院生物化学与分子生物学教研室，湛江 524000) 摘要：细胞能量异常是肿瘤细胞的十大特征之一。快速增殖的癌细胞生长所需要的能量主要是由糖酵 解而非氧化磷酸化提供，癌细胞这种特殊的糖代谢被称为Warburg效应。近年来肿瘤的靶向治疗成为 研究的热点，异常的糖酵解、脂代谢和氨基酸代谢的过程涉及到大量的限速酶和关键酶，这些都是潜 在的药物治疗靶点。本文仅围绕着调控癌细胞糖酵解进程中直接调控的关键酶和限速酶，脂代谢过程 中脂肪酸合成酶和谷氨酰胺代谢过程中的谷氨酰胺酶进行分析和综述。 关键词：肿瘤；能量代谢；治疗靶点 Potential therapeutic target of energy metabolism for cancer LIN Biyun, LI Xu, ZHANG Haitao* (Department of Biochemistry and Molecular Biology of Guangdong Medical College, Zhanjiang 524000) Abstract: Deregulation of cellular energetics is one of the hallmarks of cancer cells. Previous study has indicated that energy is acquired mainly via glycolysis rather than oxidative phosphorylation in the presence of sufficient oxygen levels to promote the rapid proliferation of cells, such as cancer cells which phenomenon is called the “Warburg effect”. In recent years, targeted therapy becomes a hot research point, the abnormal process of glycolysis, lipid metabolism and amino acid metabolism involves many key enzymes, which is po- tential targets for drug therapy. This article only has analyzed and reviewed the speed limit of key enzyme di- rectly regulating in the process of glycolysis of the cancer cells, the fatty acid synthase in the process of lipid metabolism and the glutamine in the process of glutamine metabolic enzymes. Key Words: cancer; energy metabolism; cancer therapy 细胞能量异常是肿瘤细胞的十大特征之一， 进行分析和综述。 肿瘤细胞异常的能量代谢与正常细胞有着很大的 1 糖酵解过程中潜在的治疗靶点 差别。正常细胞主要利用氧化磷酸化获取能量维 己糖激酶Ⅱ Ⅱ Ⅱ 持细胞的正常生长，而肿瘤细胞更倾向于利用有 1.1 (Hexokinase , HK ) 氧糖酵解来获取细胞