Metaregression_SPSS.pptVIP

gbiondizoccai@ gbiondizoccai@ gbiondizoccai@ Tips and tricks for performing standard meta-regression analysis with SPSS Giuseppe Biondi Zoccai Division of Cardiology, Department of Internal Medicine, University of Turin, Turin, ItalyMeta-analysis and Evidence-based medicine Training in Cardiology (METCARDIO), Turin, Italy Some bare facts A meta-regression analysis is a type of statistical analysis exploiting datasets build during systematic reviews It quantitatively explores interactions between a given effect (eg the risk of an event in patients treated with A vs B, as expressed with odds ratios) and a moderator or covariate of interest (eg prevalence of diabetes mellitus in each study) The key aspect of meta-regression is that each single study is given a specific weight which corresponds to its precision and/or size (to performed a weighted least squares [WLS] linear regression) Building your dataset To perform a standard (fixed-effect) meta-regression analysis with SPSS, it is crucial to compute and extract from each individual study: Natural log of odds ratios (OR): ln OR Standard error (SE) of OR (or √variance) Variance of OR (or SE2) Inverse of variance: 1/variance Sample size: N Moderators (ie covariates or independent variables) of interest (eg prevalence [in %] of diabetes mellitus [DM] in each study) Building your dataset Inverse of variance Moderator or covariate (eg DM) Ln OR Sample size Scatterplot Analysis with SPSS Analysis with SPSS Inverse of variance Moderator or covariate (eg DM) Dependent variable (ln OR) Results with SPSS P value for interaction Beta (meta-regression coefficient) Reporting results In our example, we can conclude that we found a significant interaction between the treatment of interest vs the comparator (expressed as ln OR) and the prevalence of diabetes (beta=-6,9, p0.001). Thus treatment A becomes significantly more beneficial than treatment B with an increasing prevalence of diabetes Further details Any SPSS versio