奥氮平与利培酮治疗痴呆精神行为症状的疗效及安全性比较研究.docVIP

奥氮平与利培酮治疗痴呆精神行为症状的疗效及安全性比较研究 　　摘要：目的 探讨奥氮平与利培酮治疗痴呆精神行为症状的临床效果以及安全性。方法 将我院2013年1月～2014年1月收治的70例患有痴呆精神行为症状的患者随机分成对照组和治疗组，对照组行利培酮进行治疗，治疗组行奥氮平进行治疗，比较两组患者的治疗效果。结果 治疗后，治疗组总有效率为85.71%，对照组为91.43%，对比显示差异无统计学意义（P0.05）；与治疗前相比，两组患者治疗2、4、8w后的BEHAVE-AD评分均有明显改善，且差异显示具有统计学意义（P0.05）；治疗组不良反应率为11.43%，明显低于对照组的31.43%，且差异显示具有统计学意义（P0.05）。结论 奥氮平与利培酮治疗痴呆精神行为症状均具有一定的临床效果，但奥氮平安全性更为显著，可降低不良反应事件的发生，帮助患者获得更好地治疗，值得推广。 　　关键词：奥氮平；利培酮；痴呆精神行为症状；疗效；安全性 　　Abstract：Objective To investigate the Olanzapine and risperidone in the treatment of dementia behavioral and psychological symptoms of clinical effects and safety. Methods 70 cases of behavioral and psychological symptoms of dementia patients in our hospital from January 2013 to January 2014 were treated randomly divided into control group and the treatment group and the control group were treated with risperidone， the treatment group were carried Olanzapine therapy， therapeutic effects were compared. Results After treatment， the treatment group， the total effective rate was 85.71%， the control group was 91.43%， compared to show no significant difference （P 0.05）； compared with before treatment， the two groups of patients after treatment BEHAVE 2，4，8w -AD scores showed significant improvement， and show a statistically significant difference （P 0.05）； adverse reaction rate was 11.43% in treatment group was significantly 31.43% lower than the control group， and the difference was statistically significant display （P0.05）. Conclusion Olanzapine and risperidone behavioral and psychological symptoms of dementia have some clinical effect， but Olanzapine security even more significant， can reduce the incidence of adverse events， help patients get better treatment， worthy of promotion. 　　Key words：Olanzapine； Risperidone； Behavioral and psychological symptoms of dementia； Efficacy； Safety 　　痴呆在临床上是一种常见的老年疾病，即指在意识清醒状态下，出现多种功能障碍的智能损害综合征。痴呆患者的临床表现因造成痴呆的病因不同而呈现出不同的特点，并且在不同时期也会存在不同的症状，主要分为认知功能障碍及非认知功能障碍[1，2]。其中认知功能障碍包括记忆障碍、运动能力紊乱、语言障碍等诸多方面，且运动能力障碍是患者丧失社会