肾上腺髓质素（Adrenomedullin）—体内最强的内源性心、肾和.ppt

肾上腺髓质素(Adrenomedullin）—体内最强的内源性心、肾和血管保护肽 北京大学医学部生理和病理生理学系 北京大学第一医院心血管病研究所 唐朝枢 生物活性小分子物质—复杂网络调节 Adrenomedullin (ADM) Kitamura K，et al. Adrenomedullin: a novel hypotensive peptide isolated from human paeochromocytoma。BBRC, 1993; 192: 553–560. ADM的细胞来源 Vascular smooth muscle cells, endothelial cells, fibroblasts Cardiac Myocytes, fibroblast, epicardium Adipocytes Chromaffin cells Osteoblasts Neuron, astrocytes Macrophages  ADM——Multifunctional Factor ADM——Multifunctional Factor ADM——Multifunctional Factor ADM—心、肾、血管疾病时内源性防御体系 Heart failure Myocardial infarction ischemia/repergusion injury Atherosclerosis Hypertension Pulmonary hypertension Renal failure Septic shock Diabetes mellitus Vascular calcification pregnancy-induced hypertension syndrome preproADM45-92（MR-proADM)--BioMarker of disease 冠心病 The MR-proADM may represent a clinically useful marker of prognosis after AMI. 心功能不全 The MR-proADM may represent a prognostic marker in patients with acute destabilized heart failure 糖尿病 Increased MR-proADM involved in the pathogenesis of diabetic vasculopathy. 脓毒血症 MR-proADM may represent a clinically useful marker of prognosis accuracy after sepsis ADM生物学效应的受体机制 新肽: Intermedin(IMD)/Arenomedullin(ADM2) Roh J, et al. J. Biol. Chem. 279 (2004) 7264–7274. Takei Y, et al. FEBS Lett. 556 (2004) 53–58. ) ADM2强于ADM可能是更有效的 心肾血管保护分子 Chronic hypoxic pulmonary hypertensive rats [Acta Physiologica Sinica, 2007; 59(2): 210-4.] Hypertension [Eur J Pharmacol, 2007; 558(1-3): 128-32] [J Pharmacol Exp Ther, 2006; 316(3): 1269-81; Cell Physiol Biochem, 2007; 20: 269–282] Myocardial ischemia [Eur J Pharmacol, 2006; 549(1-3): 117-23] Ischemia/reperfusion injury [Peptides 2005; 26(3): 501-7; B B R C 2005; 327(3): 713-9] Cardiac Hypertrophy [Peptides, 2006; 26: 1640–1646] Cerebr