10-8-4+Glycogen+Metabolism.pptVIP

* Glycogen Metabolism Glycogen Breakdown Glycogen Synthesis Glycogen Storage Diseases Glycogen Glycogen serves as storage carbohydrate in animals, insects and fungi Heavily branched to allow rapid mobilization of Glc Why use glycogen for energy storage? Muscles cannot mobilize fat as rapidly as glycogen. Fatty acid residues of fat cannot be metabolized anaerobically. Animals cannot convert fatty acids to Glc, so fat metabolism alone cannot adequately maintain essential blood Glc levels. Glycogen Breakdown Requires Three Enzymes A. Glycogen phosphorylase to cleave a1,4 linkages C. Phos