基于音圈直线驱动的无针注射技术.pdfVIP

第47卷第9期 2011年5月 机械工程学报 JOURNAL OF MECHANICAL ENGINEERING v01．47 NO．9 May 2011 DoI：10．3901，JME．2011．09．151 基于音圈直线驱动的无针注射技术木 陈凯杨锋雷 (杭州电子科技大学机械工程学院杭州310018) 摘要：针对普通以弹簧或压缩气体为动力的液体无针注射系统的缺陷，构建一种基于音圈直线驱动器的无针注射系统，并对 该系统的喷射注射机理进行理论研究，建立喷射注射的喷射压力与系统参数(如喷孔、腔体尺寸、音圈驱动器放电电压等)之 间的理论模型。搭建测量喷射压力的试验系统，并对喷射压力进行动态测试，试验结果与理论模型相吻合。对所构建的基于 音圈直线驱动器的无针注射系统进行动物注射试验，并用针刺注射作为对照组。试验表明这种电磁力驱动的无针注射技术能 产生足以穿刺皮肤的喷射压力，并具有喷射注射所特有的快速体内吸收效果。该无针注射系统具有结构简单、双向运行、压 力可控等特点，有效地克服了传统无针注射技术的缺陷，为新型无针注射系统产品的研发打下了基础。 关键词：音圈驱动无针注射喷射压力 中图分类号：THll TP6 Needle．ftee Liquid Injection System Powered by Voice．coil Linear Actuator CHEN Kai YANG Fenglei (School of Mechanical Engineering，Hangzhou Dianzi University,Hangzhou 3 1 00 1 8) Ab蚰aet：A needle-free injection system powered by a voice-coil linear actuator is presented in order to overcome drawbacks ofthe conlmon spring or compressed gas powered injection system．The mechanics of injection process is investigated．A theoretical model is established to evaluate the injection pressure under system conditions(nozzle diameter,ampoule dimension,voice-coil discharging voltage，etc．)．An experimental system is set叩to measure the injection pressure dynamically．The experimental results agICC well with the predicted values given by the theoretical model．In-vitro injections using the current needle-free system arc carried out with needle injection as contr01．Results show that the current magnetic force injection technology can generate enough injection pressure to pierce into妣and the administration is absorbed in vivo faster than that through埘眦．The current system features simple 咖lc臼l聆，two-way operation,and controllable driving force，thus overcoming the disadvantages of traditional needle—free injection systems，and laying the foundation for the product development ofnovel needle-free injection system． Key words：Voice-coil actuator Necdle-free injection Injection pressure 。0前言 常用的无针注射技术是一种通过压缩弹簧或 压缩气体产生高速射流，由微型喷孔直接射入皮下 组织的给药技术。喷射注射技术与传统的有针注射 相比，具有一系列优点：操作简单、吸收效果好、 能减少注射疼痛、消除针刺伤痛感染、减少针