脓毒症失和谐现象及对策幻灯片.pptVIP

主要信息2的故事点：乌司他丁抗炎机制 1. Caroline M, et al. Journal of Cell Science 116, 1863-1873(2003) 2. Naohiro Kanayama, et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 238, 560–564 (1997) 3. Hidenori Matsuzaki, et al. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, Nov. 2004, p. 1140–1147 4. Seiji Kanayama, et al. Journal of Endotoxin Research 2007 13: 369 Ca2+ Ca2+ Ca2+ Ca2+ Ca+ Ca2+ Ca2+ TNF-a 刺激因子 Ca2+ ERK1/2 磷酸化 NF-кB/Egr-1活化 TNF-a/IL-1? TNF-a TNF-a TNF-a TNF-a TNF-a 硫酸软骨素糖链 结合Ca2+ 结合细胞 X X X 抑制钙内流，阻断信号转导，减少TNF-a/IL-1?产生 X 稳定细胞膜,抑制TNF-a/IL-1?释放，阻断炎症级联反应 稳定溶酶体