BIO2000 discussion-summary about brown-fat-like development.ppt

A PGC1-a-dependent myokine thatdrives brown-fat-like development ofwhite fat and thermogenesis SIBCB.胡纯一 NATURE ARTICLE Exercise improvemetabolic status in obesity and type 2 diabetes ？ adipose tissues energy expenditure PPAR-c PGC1-a IRISIN FNDC5 PPAR-a thermogenisis gene ucp1 prdm16 cidea adipoq white fat cell brown fat cell TRANSGENIC MICE PGC1-a BROWNING subcutaneous depot 1. 2. FNDC5 PGC1-a EXERCISE BROWNING 3. FNDC5 PPAR-a 4. FNDC5 IRISIN cleaved secret glycosylation 5. Irisin browning highlights 1.it identifies a new myokine, irisin, that acts on fat depots to enhance thermogenesis. 2 IRISIN is proved for the first time byprotease excision C end of FNDC5,thuns to be a secretory protein. 3.the therapeutic potential of IRISIN is huge . 4.The paper also shows some fascinating differences in the gene response of muscle to exercise between mice and humans. 5.This may also provide further insights into the cross-talk between different muscle and fat depots. limites the data on irisin in humans are limited at the moment and this will require more elaborate analyses in the future. The fact that human and mouse irisin are 100% identical is encouraging. they didnt show the data from the diabetic subjects and they showed data from only eight subjects from the original clinical trial. they have not provided further insights into the cross-talk between different muscle and fat depots. Endurance exercise vs Transient training DISSENT FNDC5 is not activated by training Keller et al. J Appl Physiol 2011, 110:46-59 Timmons et al. FASEB J 2005, 19:750-60 uncoupling protein 1 (UCP1) induction by irisin is extremely modest (ten times lower than during brite formation ) Petrovic et al. J Biol Chem 2010, 285:7153-64 Followed new questions what is the recepto