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Electrochemical detector
Gut, 1981, 22, 836-840
Electrochemical detector for breath hydrogen
determination: measurement of small bowel transit
time in normal subjects and patients with the irritable
bowel syndrome
C L CORBETT,* S THOMAS, N W READ, N HOBSON,
I BERGMAN, AND C D HOLDSWORTH
From the Gastroenterology Unit, Royal Hallamshire Hospital, Sheffield, and Health and Safety
Executive Laboratories, Sheffield
SUMMARY A method is described for the measurement of hydrogen in expired air, using an
electrochemical detector. The apparatus is simple to use and sensitive. Its application is illus-
trated by studies of small bowel transit time made by measuring the time between oral ingestion
of the unabsorbable carbohydrate lactulose and a rise in the concentration of hydrogen in ex-
pired air. In 20 control subjects transit time was 93.0±6.6 minutes, while in 16 patients with
diarrhoea due to the irritable bowel syndrome it was 541-+6±3 minutes (PO0OOI), suggesting
an abnormality in small intestinal motility in these patients. Loperamide, a potent antidiarrhoeal
agent, increased transit time in 12 of these patients from 56.3±6.7 to 100-0±102 minutes
(pO00 1).
The measurement of hydrogen in expired air has
found an increasing number of applications, in-
cluding the detection of small bowel bacterial
colonisation and disaccharidase deficiency,2 the
detection and quantification of carbohydrate mal-
absorption,-; and the measurement of small bowel
transit time.- The concentration of hydrogen
in expired air is conventionally measured by gas
chromatography using a thermal conductivity de-
tector.10 11 Such apparatus is expensive and not
universally available. This report describes the use
of an electrochemical detector, which, when com-
bined with a simple chromatographic system,
allows rapid and sensitive measurement of breath
hydrogen. We report its application to the
measurement of small bowel transit time in normal
control subjects and in patients with diarrhoea
attributed to the irritable bowel
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