A comparison of effects of sequential transdermal administration.pdf

下载文档

10
0
约2.84万字
约 7页
2017-04-11 发布于江苏
举报
版权申诉
保障服务

A comparison of effects of sequential transdermal administration.pdf

1、本文档共7页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

A comparison of effects of sequential transdermal administration

Maturitas 53 (2006) 32–38 A comparison of effects of sequential transdermal administration versus oral administration of estradiol plus norethisterone acetate on serum NO levels in postmenopausal women Gulay Kurtay a , Batuhan Ozmen b, ? , Imge Erguder c a Menopause Clinic, Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University, Ankara, Turkey b Reproductive Health and Infertility Clinic, Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University, Uyum Sit. No. 28, Cayyolu-Konutkent, Ankara, Turkey c Department of Biochemistry, Faculty of Medicine, Ankara University, Ankara, Turkey Received 16 February 2004; received in revised form 22 January 2005; accepted 1 February 2005 Abstract Aim: To compare the effects of sequential transdermal administration versus oral administration of estradiol plus NETA on serum nitric oxide (NO) levels in postmenopausal women (PMW). Materials and methods: Eighty postmenopausal subjects without any prior hormone replacement therapy (HRT) usage were enrolled in this study. All participants were healthy, ambulatory, non-smoker and had similar life styles with dietary habits. HRT was given to participants according to desired HRT administration, in group A (n= 50); oral estradiol hemi-hydrate ( a u t R a B s C c ? K f 02 mg)/norethisterone acetate (1 mg), and in group B (n= 30); transdermal combined patch comprising estradiol (0.05 mg) alone nd estradiol (0.05 mg)/norethisterone acetate (0.25 mg), were given sequential for 12 months. Serum NO levels were studied sing Total Oxide Assay Kit (Assay Designs, Inc.) according to manufacturer’s instructions prior to and after 12 months from he HRT treatment. esults: The mean serum NO levels prior to the HRT in groups A and B was 0.48± 0.46 (range, 0.27–0.76 nmol/mL) nmol/mL nd 0.47± 0.48 nmol/mL (range, 0.29–0.693 nmol/mL) (p 0.05). The mean serum NO levels after the HRT in groups A and was 0.53± 0.33 nmol/mL (range, 0.29–2.10 nmol/mL) and 2.91± 0.50