An Introduction to Micro-nano-Bubbles and their Applications.pdf

An Introduction to Micro/ano-Bubbles and their Applications TOMOHIRO MARUI ano Bubble Technologies LLC General Manager, Technical Department (Futyu Laboratory) 3-7-5 Futyu town Futyu city 183-0055 Tokyo, JAPA ABSTRACT Micro-bubbles gradually decrease in size due to the dissolution of interior gases by the surrounding liquid and eventually disappear, leaving some Nano-Bubbles. It has been proved that free radicals are generated during the collapsing of Micro-bubbles. The present introduction focuses on the biological application of Micro/Nano-bubbles, whose practical bio- applications, development of cell-level biological treatment, and concept of cell manipulating device in the next stage of the development are introduced. In addition, the future application of Micro/Nano-bubbles to Bio-computing systems is also discussed. Keywords: micro/nano-bubbles, radicals, fermentation, ES- cells, iPS-cells, Taylor vortex, Couette-Taylor reactor, cell- sorting, bio-computer, bio-computing. 1. ITRODUCTIO Both Scientific researches and practical applications of Micro/Nano-bubbles were greatly promoted by Hirofumi Ohnari (Tokuyama National College of Technology, CEO of Nanoplanet), Masayoshi Takahashi (National Institute of Advanced Industrial Science and Technology (AIST)), and Kaneo Chiba (REO Laboratory) recently. [1-6] With other contributors’ efforts, Micro-bubbles (micron scaled bubbles) and Nano-bubbles (nano scaled bubbles) are gathering increasing interest in industrial fields because their properties are so different from those of mill-scaled bubbles. Fig.1. Micro-bubbles and mill-scaled bubbles [1] Fig.1 schematically illustrates the differences in the behaviors between mill scaled bubbles and Micro-bubbles. The former rise rapidly and burst on the liquid surface, whereas the latter keep stable for long periods and gradually decrease in size due to the dissolution of interior gases by the surrounding liquid