Proteomic analysis of brain proteins in APPPS-1 human double mutant knock-in mice.pdfVIP

RESEARCH ARTICLE Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid b-peptide deposition: Insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer’s disease Rena? A. S. Robinson1, Gururaj Joshi1, Quanzhen Huang1, Rukhsana Sultana1, Austin S. Baker1, Jian Cai2, William Pierce2, Daret K. St. Clair3, William R. Markesbery 4,5 y and D. Allan Butterfield1,4,6 1 Department of Chemistry, University of Kentucky, Lexington, KY, USA 2 Department of Pharma