VeriSeqPGSSolutionontheMiSeq.PDFVIP

Data Sheet: Reproductive and Genetic Health VeriSeq? PGS Solution on the MiSeq? System A next-generation sequencing solution for PGS, providing accurate results in aneuploidy screening and extending future opportunities. Highlights ? Industry-Leading Data Quality 90% of sequencing data in the world was generated using Illumina technology ? Fast, Streamlined Workflow Sample to result is approximately 12 hours ? High-Throughput Scalable Solution Screen up to 24 samples per run Figure 1: The MiSeq System. The VeriSeq PGS Solution Introduction leverages Illumina SBS chemistry on the MiSeq System for reliable, accurate PGS. Chromosome aneuploidy (an abnormal number of chromosomes) is a major cause of in vitro fertilization Illumina sequencing delivers the most accurate human (IVF) failure as most embryos with aneuploidy will not genome at any coverage, the highest yield of error-free implant or will miscarry during the first trimester of reads, and the highest percentage of base calls above * pregnancy.1,2 Preimplantation genetic screening (PGS) Q30 in the industry. Such high data quality results in low false positive and false negative rates, reducing the need for euploid embryos, those embryos with a normal for extensive downstream validation while providing full number of chromosomes, increases the chance that confidence in the data. a viable embryo will be selected for transfer and the likelihood of successful implantation and pregnancy.3 Flexible MiSeq