FibrogenesisTissueRepair.PDFVIP

Fibrogenesis Tissue Repair BioMed Central Research Open Access Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty Theresa A Freeman1, Javad Parvizi2, Craig J Della Valle3 and Marla J Steinbeck*4 Address: 1Department of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Suite 501, Philadelphia, PA 19107, USA, 2The Rothman Institute of Orthopedics at Thomas Jefferson University, Market Street Philadelphia, PA 19107, USA, 3Department of Orthopaedic Surgery, Rush University Medical Center, 1725 W Harrison Street, Suite 1063, Chicago, IL 60612, USA and 4Department of Biomedical Engineering and Department of Drexel Medicine, Drexel University, 3120 Market Street, 323 Bossone, Philadelphia, PA 19104, USA Email: Theresa A Freeman - theresa.freeman@; Javad Parvizi - parvj@; Craig J Della Valle - craigdv@; Marla J Steinbeck* - mjs348@ * Corresponding author Published: 13 November 2009 Received: 15 July 2009 Accepted: 13 November 2009 Fibrogenesis Tissue Repair 2009, 2:5 doi:10.1186/1755-1536-2-5 This article is available from: /content/2/1/5 ? 2009 Freeman et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Arthrofibrosis, occurring in 3%-4% of patients following total knee arthroplasty (TKA), is a challenging condition for which there is no defined cause. The hypothesis for this study was that disregulated production of reactive oxygen