人体生物化学与疾病讲解.ppt

《人体生物化学与疾病》;*;*;*;*;*;*;*;*;脑脊液的循环;*;*;脑脊液的成分特点： 微量的蛋白质 较少的葡萄糖 较多的电解质;*;*;*;*;*;*;*;*;分类;*;*;名称;*;*;*;*;*;*;*;*;*;*;*;*;*;　 脑脊液中常用神经递质的检测及临床意义 ;*;;;*;;*;;;*;*;*;*;*;*;*;*;*;*;*;*;*;*;*;*;History of Alzheimer’s Disease;The Case Auguste Deter;回间沟;*;*;*;*;*;Pathophysiology from Tau;Changes in Tau protein lead to microtubule desintegration;Genetics;*;Diagnosis of Alzheimer’s Disease – The Future;Improving Diagnosis of AD by Blood CSF Study;Molecular Functional PET in AD;Increasing aged population;*;*;*;*;*;*;What is amyotrophic lateral sclerosis?;Significance of the Name of this Disease;Other common names for this disease:;Who was Lou Gehrig?;What genes are related to ALS?;This disease affects SOD1 gene on chromosome 21;Cu/Zn Superoxide dismutase 1 gene;Structure of SOD1 Protein; SOD1 protein;Mutations in SOD1 protein;Mutations in SOD1 protein continued . . . ;;Nature and Characteristics of ALS;ALS continued . . . ;Who Gets ALS?;Cause of ALS;Symptoms of ALS;Symptoms continued . . . ;This picture from the Neuromuscular website shows the wasting away of a person’s hands and arms;Symptoms, or patterns of symptoms, are not the same for each ALS individual However, progressive muscle weakness and paralysis are universally experienced Since ALS attacks only motor neurons, the sense of sight, touch, hearing, taste, and smell are not affected Patients usually only live 3 to 5 years after they are diagnosed There are some cases; however, where individuals have lived 10 or more years;Diagnosing ALS;Medication for ALS;Hypothesis;Hypothesis #1 ;Support from NCBI;Picture from The ALS Society of Canada;Support continued . . .;Hypothesis #2;From MDA Publications;Support from NCBI;Support continued . . .