2006chen sheng peng SCI星状神经节信号活动的生理变化.pdf

C a B S C a M b c A s c S A L R C M i 1ircadian variations of stellate ganglion nerve activity in mbulatory dogs yung-Chun Jung,a Amish S. Dave,a Alex Y. Tan,a Ghassan Gholmieh,c hengmei Zhou,a David C. Wang,a A. George Akingba,b Gregory A. Fishbein,a arlo Montemagno,b Shien-Fong Lin,a Lan S. Chen,c Peng-Sheng Chena From the Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of edicine, UCLA, Los Angeles, California, Department of Bioengineering, UCLA, Los Angeles, California, and Department of Neurology, Childrens Hospital and the Keck School of Medicine, University of Southern California, Los ngeles, California.BACKGROUND The presence of circadian variations in sympathetic outflow from the stellate ganglia is unclear. OBJECTIVES The purpose of this study was to continuously record stellate ganglion nerve activity (SGNA) in ambulatory dogs. METHODS We performed continuous 24-hour left (N
3) or bilateral (N
3) SGNA recordings in normal ambulatory dogs using implanted Data Sciences International transmitters. We also performed simultaneous ECG recording (n
5) or simultaneous ECG and blood pressure recordings (n
1). RESULTS The total duration of continuous ambulatory recording averaged 41.5  16.6 days. Five dogs had persistent stable recording, and one dog developed hardware malfunction in week 3. SGNA was followed immediately (1 second) by heart rate and blood pressure elevation and a reduced standard deviation of consecutive activation cycle length (SDNN) from 236  93 ms to 121  51 ms (P
0.007). Heart rate correlated significantly with SGNA. When there was a sudden increase of SGNA, the sudden increase occurred bilaterally in 90% of the episodes. Both heart rate and SGNA showed statistically significant (P .01) circadian variation. Nadolol (20 mg/day for 5 days) reduced average heart rate from 99  8 bpm at baseline to 88  9 bpm (N
6, P
.001) but did not significantly alter SGNA. Immunohistochemica