Double-Regulated Oncolytic Adenovirus-Mediated.pdfVIP

Double-Regulated Oncolytic Adenovirus-Mediated Interleukin-24 Overexpression Exhibits Potent Antitumor Activity on Gastric Adenocarcinoma Na Wei,1 Jun Kai Fan,1 Jin Fa Gu,1 and Xin Yuan Liu1,2 Abstract Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24), identified by subtraction hybridiza- tion in the mid-1990s, is a potent gene therapeutic for cancer. Using a replication-deficient adenovirus as vector, it provokes apoptosis in diverse cancer cells without harming normal cells or tissues. To exploit the anticancer capability of IL-24 to the best, in this study, we generate