complement补体课件1.pptVIP

CAPTER 5 COMPLEMENT（补体）;DEFINITION; What is complement ;A group of heat-labile normal proteins which distribute in serum,humour and some cell membrane.They closely relate to the immune function and have enzymatic activation after actived（分布于血清，体液和一些细胞膜表面的一组热不稳定正常蛋白。与免疫功能紧密相关，活化后具有酶活性） What is the property of the complement （补体有和特点）;1. heat-labile （热不稳定） 2. normal proteins ,is independent of antigen stimulation（正常蛋白，与抗原刺激无关） 3.not a singly,there are about 30 kind of protein consist of a group,called complement system（不是一个单一成分，大约30种蛋白组成补体系统） 4.have enzymatic activation（具有酶活性） 5.play an important rloe in immune function（在免疫功能中发挥重要作用）;The consist of complement system（补体系统的组成）;THE PATHWAY OF COMPLEMENT ACTIVATED（补体活化途径）;THREE DIFFERENT PATHWAYS（三条途径） 1. Classical pathway（经典途径） 2.Alternative pathway（替代途径） 3.Lectin pathway（凝集素途径，MBL途径）;CLASSICAL PATHWAY;The condition of Complement activation via the classical pathway（经典途径活化补体的条件） ;The actived process（活化过程）;C1 recognize antigen-antibody complex（C1对抗原-抗体复合物的识别）;;;;;The activation of complemant（补体的活化）;; ; ;;;The Lysis. of Target（靶细胞的溶解）;;;;;;Ca++;Classical Pathway Generation of C3-convertase ;Classical Pathway Generation of C5-convertase;Lytic pathwayC5-activation;Lytic pathwayassembly of the lytic complex;Lytic pathway:insertion of lytic complex into cell membrane;ALTERNATIVE PATHWAY（替代途径）;The condition of Complement activation via the alternative pathway（替代途径活化的条件）;激活物质 细菌内毒素、酵母多糖、葡聚糖、凝集的IgA和IgG4等 B C3 C3b C3bB C3bBb C3a C3a Ba C3b D