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一个新的癌基因和重要转录辅激活因子HBXIP在肿瘤中的作用及其调节机制研究;
癌基因HBXIP的发现; You JC and Ye LH, et al. Endocrinology, 2009 ;150(4):1607-17 (IF5.1)
;Zhou X and Ye LH*, et al. Cancer Letters 2008; 270:312-327. (IF4.9)
Hu N and Ye LH et al, et al. Acta Pharmacol Sin. 2011; 2011;32:921-929
;Shan C and Ye LH et al, et al. Cell Res. 2010 20(5):563-75(IF9.4)
;
;Wang F and Ye LH et al. Acta Pharmacologica Sinica. 2008; 29(1).83-89.
Wang F and Ye LH et al. Acta Pharmacologica Sinica.2007;28(3) : 431-438
Wang F and Ye LH et .Progress in Biochemistry Biophysics 2007;34(11):1171-1201
;;;重要转录辅激活因子HBXIP在肿瘤中的作用及其调节机制研究;HBXIP upregulates s100a4 via stat4 and pten to promote growth
and migration of breast cancer cells. ;Yue L and Ye, L et al.Carcinogenesis, 2013 Jan 5. [Epub ahead of print] IF=5.7;HBXIP Up-regulates Lin28B via HBXIP/TFⅡD/Lin28B/miR-520b/h/HBXIP Feedback Loop to Maintain High Proliferation of Breast Cancer Cell ;The oncoprotein HBXIP induces EMT and migration of breast cancer cells through coupling NM-IIA disassembling and filopodia formation;The nuclear import of oncoprotein HBXIP requires interaction with c-Fos and their phosphorylation in breast cancer cells ;;HBXIP Is Negatively Related to the Survival of Breast Cancer Patients ;The clinical significance of HBXIP in breast cancer;; HBXIP Promotes the Growth of Breast Cancer by Upregulating FAS;The cellular localization of HBXIP;HBXIP upregulates SREBP-1c;HBXIP upregulates FAS by stimulating SREBP-1c ;HBXIP binds to the boxes of LXRE in SREBP-1c promoter region;HBXIP activates SREBP-1c promoter involving LXRE;HBXIP is required for the binding of LXR to the
promoter region of SREBP-1c;;HBXIP directly interacts with LXRs;HBXIP Upregulates SREBP-1c in Several Tumor and Cell Lines ;Corepressor/coactivator exchange complexes are targets of multiple extracellular and intracellular signaling pathways;HBXIP stimulates the SREBP-1c promoter independently of ligands;HBXIP is synergistically capable of binding the SREBP-1c promoter throu
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