吴田基层医学.docVIP

作者单位：山东省单县中心医院肿瘤科（274300） 作者：吴田（1967～）主治医师，email: wutian0627@. 电话复方苦参注射液联合FOLFOX4方案治疗晚期胃癌疗效观察 吴田 刘德玲 张雪玲 刘付花 [摘要] 目的 探讨复方苦参注射液联合FOLFOX4方案治疗晚期胃癌的临床疗效及毒副反应,。方法 65例经病理确诊的晚期胃癌患者随机分为两组，治疗组34例，采用复方苦参注射液联合FOLFOX4方案化疗：草酸铂85 mg/m2，静滴2h（先入），第1天；甲酰四氢叶酸钙200 mg/m2 ，静滴2h，第1～3天；5-氟脲嘧啶400 mg/m2,快速静注,追加600 mg/m2,持续静滴22h,第1～3天。同期静脉滴注复方苦参注射液20ml，1次/d，连用14天后，休息14天，28天为一个周期。对照组31例，单纯采用FOLFOX4方案化疗，草酸铂、甲酰四氢叶酸钙和5-氟脲嘧啶用法同治疗组。对两组的总反应率﹑毒副反应﹑生活质量改善率﹑中位进展时间（MTTP）和中位生存期（MST）作回顾性分析。结果 治疗组与对照组的总反应率分别为58.8%（20/34）和48.4%（15/31），无显著性差异（X2=0.71, P0.05）;完全缓解率分别为20.6%（7/34）和3.2%(1/31), 有显著性差异（X2=4.53 , P0.05）;试验组胃肠道反应和骨髓抑制较对照组减轻，差异有统计学意义（p0.05）；试验组化疗后KPS评分明显高于对照组（p0.01）。生活质量改善率分别为82.6%和60.0%,有显著性差异（X2=4.78，P0.05）。MTTP及MST差异亦具有显著性。结论 复方苦参注射液联合FOLFOX4方案治疗晚期胃癌的疗效较好，患者不良反应轻，具有改善患者生活质量的作用。 [主题词] 复方苦参注射液；FOLFOX4方案；联合；晚期胃癌 Therapeutic Effects of compound Kushen injection plusing FOLFOX4 Regimen on Advanced Gastric Cancer WU Tian, LIU De-ling, ZHANG Xue-ling. LIU Fu-hua. Department of Oncology , The Central Hospital of Shanxian County, Heze, 274300 [Abstract] Objectives To explore the efficacy and toxicity of compound Kushen injection plusing FOLFOX4 Regimen in the treatment on patients with advanced gastric cancer (AGC). Methods Sixty-five patients with AGC were divided into two groups randomly, among which 34cases(treatment group) were treated by compound Kushen injection plusing FOLFOX4 Regimen: OXA 85mg/m2 iv 2h(given first) d1 , LV 200 mg/m2 iv 2h followed by 5-Fu 400 mg/m2 iv and 5-Fu 600 mg/m2 iv 22h d1～3 were given, and compound Kushen injection 20ml /d ivdrip lastfor 14d was given in the sametime.and every 28d as 1 cycle. and 31cases(control group) by FOLFOX4 regimen only.The doses and methods of OXA ,LV and 5-Fu were same as the treatment group. The overall rate of response、toxicity、improvement of QOL and progression free survivor for the two regimens were analysed retrospectively. Results The clinical characteristics of the two groups were similar(P0.05).All patients could be ev