黄芩茎叶总黄酮预防性保护脑梗死海马神经元多环节多途径多靶点的联合作战.doc

SICENCE新闻发布 作者：孔祥玉 稿号：NRR-202-14 黄芩茎叶总黄酮预防性保护脑梗死海马神经元：多环节、多途径、多靶点的联合作战 黄芩茎叶总黄酮的主要成分为黄酮类化合物，具有多羟基结构使其通过本身被氧化而保护组织细胞膜系统，间接降低自由基和醛类化合物对细胞的毒害，对超氧化物歧化酶、谷胱甘肽过氧化物酶活力及丙二醛进行综合调节，从而保护细胞的结构和功能。 中国承德医学院孔祥玉所在研究团队一项研究显示，提前1周给实验大鼠灌服黄芩茎叶提取物——黄芩茎叶总黄酮，可保护脑微血管结构，维护血脑屏障结构完整，减轻脑水肿和神经功能损伤，从而可抑制再灌注时神经元凋亡，对大脑海马组织有明显的预防性保护作用。说明其对脑缺血再灌注损伤机制不只在于维护微血管完整或阻遏了某一促凋亡信号通路，而是通过多环节，多途径、多靶点共同起到对海马组织发挥了预防性保护作用，实验结果为临床防治缺血性脑卒中开辟了新途径。相关文献发表于《中国神经再生研究（英文版）》杂志2014年12月第23期。 免疫组换染色显示在脑缺血再灌注损伤前1周给予大鼠黄芩茎叶总黄酮100mg/kg/d灌胃，可以减轻大脑海马中Fas的表达 Article: Pretreatment with scutellaria baicalensis stem-leaf total favonoid protects against cerebral ischemia/reperfusion injury in hippocampal neurons, by Xiangyu Kong, Wei Kong, Guangxin Miao, Shumin Zhao, Meng Chen, Xiaoying Zheng, Jiangtao Bai (Laboratory of Spinal Cord Injury and Rehabilitation, Chengde Medical College, Chengde, Hebei Province, China) Kong XY, Kong W, Miao GX, Zhao SM, Chen M, Zheng XY, Bai JT. Pretreatment with scutellaria baicalensis stem-leaf total flavonoid protects against cerebral ischemia/reperfusion injury in hippocampal neurons. Neural Regen Res. 2014;9(23):2066-2073. SSTF pretreatment prevents against cerebral ischemia-reperfusion injury The flavonoids are the main components of scutellaria baicalensis stem-leaf total flavonoid (SSTF). Because of the multi-hydroxy structure, flavonoids can be self-oxidized to protect cell membrane systems, indirectly attenuate the impairment caused by free radicals and toxic aldehydes, and regulate superoxide dismutase and glutathione peroxidase activities and malondialdehyde content, thereby protecting the cells. Xiangyu Kong, Chengde Medical College, China and his colleagues found that intragastric administration of SSTF for 1 week prior to establishment of local cerebral ischemia/reperfusion injury in rats can protect microvascular structure, maintain the integrity of blood-brain barrier, alleviate cerebral edema and neurofunctional deficits, inhibit neuron