61例遗传性大肠癌患者家系分析.docVIP

KKME---专业医学搜索引擎/ 61例遗传性大肠癌患者家系分析 　　作者：郭丽霞,耿建萍,王俊梅,瞿峰,王建英,杜　　作者单位：河北工程大学医学院,河北 邯郸 056029;2.峰峰集团精神卫生中心,河北 峰峰 056202;河北省邯郸市第二医院,河北 邯郸 056001 　　.【摘要】目的：分析遗传性大肠癌常染色体显性遗传规律，对有大肠癌遗传病史的家族后代做好预防工作，减少大肠癌的发生。方法：对61例遗传性大肠癌患者家系调查咨询及查体，分别做相关辅助检查：消化道气钡双对比造影、纤维结肠镜检查并取活检、X线平片检查、病理学检查、临床生化检查，细胞遗传学检查为外周血淋巴细胞G-显带染色体分析等。结果：遗传性大肠癌在家系中连续几代发生，当父亲或母亲获得了常染色体显性遗传时，其儿女患此病的危险率是50%。患者往往有两种或两种以上的癌肿发生。结论：有大肠癌遗传病史的家族后???，及早给予预防措施，对遗传性大肠癌患者的有效治疗具有重要意义。 　　【关键词】 大肠;肿瘤;遗传 　　【ABSTRACT】 Objective:By investigating analysis,to understand hereditary colorectal cancer autosomal dominant genetic,which can have a history of family and future generations,and also to prevent and reduce the incidence of colorectal cancer.Methods:Based on 61cases with family consultation and investigations respectively,different auxiliary examinations,inspection items which had been done were gastrointestinal double-contrast barium gas,fiber colonoscopy for biopsy,X-ray film inspection,biopsy pathological examination,Clinical labo- ratory examination,cytogenetic examination of peripheral blood lymphocytes for the G-banding chromosome analysis.Results:Hereditary colorectal cancer in successive generations occurred when the father or mother had autosomal dominant genetic disease,their sons and daughters with the risk of developing breast cancer was 50 percent.Patients often had two or more kinds of the cancer occurred.Conclusion:Investigation of the genetic history for colorectal cancer has a family and future generations.To prevent or find micro-transfer and micro-transfer tendency of colorectal cancer as early as possible,and taking effective treatment are of great significance. 　　【KEY WORDS】 Intestine Large,Neoplasms,Heredity 　　遗传性大肠癌包括家族性腺瘤性息肉病、遗传性非息肉病性大肠癌、家族性大肠癌，在其发病过程中，遗传因素起到重要作用[1]，表现为常染色体显性遗传，患者子女发病率50%，男女发病机会均等[2]。我们对7个家系的61例遗传性大肠癌患者家系发病情况进行了分析，以期进一步明确其遗传规律，探讨早期防治措施。 　　1 资料与方法 　　1.1 一般资料 　　7个家系的61例遗传性大肠癌患者。 　　1.2 方法 　　根据对家系调查咨询及查体分别做不同的辅助检查。检查项目有：消化道气钡双对比造影、纤维结肠镜检查并取活检、X线平片检查、病理学检查、临床