个体化医疗的现状与未来-生物标志物1幻灯片.pptVIP

个体化医疗的现状与未来四. 生物标志物研究;Outline;生物标志物的概念;什么是生物标志物(biomarker)？;Features of a Useful Biomarker;不同水平生物标志物;Biomarker Examples;生物标志物的临床应用;目前临床很多疾病的诊断依赖病理诊断，但不能作为常规筛查、监测手段 众多疾病缺乏早期、特异性生物标志物 治疗缺乏个体化方案 ;Clin J Am Soc Nephrol 3: 1895–1901, 2008.;Are we treating sub-populations?;Novel biomarkers are needed;“The use of biomarkers will change medical practice from a population-based approach to an?individualized approach” Felix Frueh, Associate Director of Genomics at CDER, FDA;Evolution of the biomarkers research;High plasma cholesterol and cardiovascular diseases;Additional biomarkers (inflammation