成纖維细胞与血液系统恶性肿瘤.docVIP

成纤维细胞与血液系统恶性肿瘤 摘要肿瘤微环境在肿瘤的发生、发展中起重要作用。参与这个微环境成分的细胞中，相较于造血系统肿瘤与实体肿瘤癌，癌症相关成纤维（CAFS）却很少受到关注。在这篇综述中，我们主要探讨CAFs参与血液系统恶性肿瘤进展和潜在的靶向癌相关纤维细胞的新的治疗角度。 关键词：肿瘤相关成纤维细胞，间充质干细胞，血液系统恶性肿瘤，肿瘤微环境 一 主要血液系统恶性肿瘤 急性白血病 急性白血病是血液系统恶性肿瘤，起源于早期造血祖细胞和髓细胞（急性髓细胞样白血病 AML）和淋巴机型淋巴性细胞白血病ALL的血统。急性白血病，可以根据细胞遗传学、形态学、免疫表型的标准和骨髓的初步发展来进一步细分。急性白血病易侵入循环系统并且发生扩散。 慢性淋巴细胞白血病（Chronic Lymphocytic Leukemia） CLL是CD19 ADDIN EN.CITE EndNoteCiteAuthorKatz/AuthorYear2014/YearRecNum22/RecNumDisplayText[1]/DisplayTextrecordrec-number22/rec-numberforeign-keyskey app=EN db-id=se5wx2zp5r9wxoepwp2pwvwdeavaxa0pxp5922/key/foreign-keysref-type name=Journal Article17/ref-typecontributorsauthorsauthorKatz, B. Z./authorauthorHerishanu, Y./author/authors/contributorsauth-addressDepartment of Hematology, Tel Aviv Sourasky Medical Center , Tel-Aviv , Israel./auth-addresstitlestitleTherapeutic targeting of CD19 in hematological malignancies: past, present, future and beyond/titlesecondary-titleLeuk Lymphoma/secondary-titlealt-titleLeukemia amp; lymphoma/alt-title/titlesperiodicalfull-titleLeuk Lymphoma/full-titleabbr-1Leukemia amp; lymphoma/abbr-1/periodicalalt-periodicalfull-titleLeuk Lymphoma/full-titleabbr-1Leukemia amp; lymphoma/abbr-1/alt-periodicalpages999-1006/pagesvolume55/volumenumber5/numberkeywordskeywordAnimals/keywordkeywordAntibodies, Monoclonal/adverse effects/*immunology/*therapeutic use/keywordkeywordAntigens, CD19/genetics/*immunology/keywordkeywordAntineoplastic Agents/adverse effects/*therapeutic use/keywordkeywordCell Transformation, Neoplastic/genetics/immunology/keywordkeywordClinical Trials as Topic/keywordkeywordDrug Evaluation, Preclinical/keywordkeywordGene Expression Regulation/keywordkeywordHematologic Neoplasms/*drug therapy/genetics/*immunology/keywordkeywordHumans/keywordkeywordMolecular Targeted Therapy/adverse effects/keyword/keywordsdatesyear2014/yearpub-datesdateMay/date/pub-dates/datesisbn1029-2403 (Electronic)#xD;1026-8022 (Linking)/isbnaccession-nuaccession-numurlsrelated-urlsur