年产160吨芬布芬工艺设计毕业论文.docVIP

年产160吨芬布芬工艺设计 盐城师范学院制药工程课程设计  PAGE 22  PAGE \* MERGEFORMAT 22 年产160吨芬布芬工艺设计 目 录 摘要2 1 引言4 2 概 述5 2.1 设计依据5 2.2产品概述5 3 缩合工段物料衡算 7 3.1 设计任务7 3.2 缩合水解反应式7 3.3 缩合水解过程各物料消耗7 3.4 原料质量标准和配比7 3.5 缩合反应罐进料以及出料8 4 缩合工段能量衡算10 4.1 缩合反应能量能量衡算相关数据10 4.2 各物质的比热计算11 4.3 熔解热计算11 4.4 热量计算11 4.5 过程热效应11 5 缩合工段设备选型13 6 劳动组织与岗位定员16 6.1 劳动组织16 6.2劳动保障与安全生产16 6.3“三废”处理及综合利用18 7 论文小结19 附： 1. 参考文献 2. 附图 年产150 吨芬布芬工艺设计 王玲玲 [摘要]本次设计为年产160 吨芬布芬的车间工艺设计。芬布芬，又名联苯丁酮酸；苯酮酸。为一较新型的长效非甾体消炎镇痛药。本设计所采用的工艺路线为：以联苯、丁二酸酐和三氯化铝为原料，加入二氯乙烷缩合后经由盐酸和水水解获得芬布芬。年产芬布芬160吨，缩合水解工段收率93.25%，精制工段收率94.94%，单程收率88.53%，总收率92.51%，回收率4.3%。成品质量标准：芬布芬纯品99%杂质及水的含量1%。设计内容主要包括芬布芬车间工艺设计依据，工艺路线论证，工艺流程设计，全流程物料衡算，能量衡算，工艺设备选型与计算，车间布置设计，工程经济，劳动保护，安全生产与“三废”处理及其综合利用等内容。设计所得成果主要有设计说明书和相应的图，其图包括车间设备平、立面布置图、带控制点的工艺流程图、物料流程框图、精烘包车间平面布置图、典型设备的装备图、典型工段配管图。 [关键词]芬布芬 车间工艺 设计 工艺路线 收率 [Abstract] The design for the annual output of 160 tons of fenbufen in the workshop process design.Fenbufen, also knownas Ding ketoacid biphenyl; benzene keto acid.For the newer long-acting non-steroidal anti-inflammatory analgesics.The designprocess used routes are: to biphenyl, succinic anhydride and aluminum chloride as the raw material, ethylene dichloride condensation and water after hydrolysis by hydrochloric acid to obtain fenbufen.Design elements include fenbufen workshop process design basis, process route feasibility studies, process design, the whole process material balance, energy balance,process equipment selection and calculation, plant layout design, engineering, economic, labor protection, safety andthree wastes and the comprehensive utilization of contents.Design from specification and design of the main results of the corresponding graph, the graph including workshop equipment, flat, vertical surface layout, with a flow chart of the control point,the material flow diagram, finishing, drying, packing workshop floor plan, typical equipment and equipment mapSection oftypical piping diagram. [