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? AGING, January 2009, Vol. 1. No 1 ? ? ??????????????????????????????????????????????? Research? paper ? Fat? ?accumulation?in?Caenorhabditis?elegans??????????????????????????????????????????????triggeredResearch?by?the?paper? ? ? electrophilic?lipid?peroxidation?product ?4‐Hydroxynonenal?(4‐HNE)? ? ? ? ?1 ?1 ?1 1,2 Sharda? ?P.?Singh, ?Maciej?Niemczyk, ?Ludwika?Zimniak, ?Piotr?Zimniak ? ? 1? ?Department?of?Pharmacology?and?Toxicology,?University?of?Arkansas?for?Medical?Sciences,?Little?Rock,?? A R?72205,?USA? 2 Central?Arkansas?Veterans?Healthcare?System,?Little?Rock,?AR?72205,?USA? ? Running ?title:?4‐HNE?triggers?fat?accumulation?in?C.?elegans? Key ?words:?Lipid?peroxidation;?4‐hydroxynonenal;?malonyl‐CoA;?acetyl‐CoA?carboxylase;?citrate;?obesity? Correspondence: ?Piotr?Zimniak,?PhD,?Department?of?Pharmacology?and?Toxicology,?University?of?Arkansas?for?Medical? Sciences, ?4301?W.?Markham?St.?Little?Rock,?AR?72205,?USA? Received: ?11/17/08;?accepted:?12/12/08;?published?on?line:?12/18/08 ? E ‐mail:?zimniakpiotr@? Copyright: ???2009?Singh?et?al.?This?is?an?open‐access?article?distributed ?under?the?terms?of?the?Creative?Commons?Attribution? License, ?which?permits?unrestricted?use,?distribution,?and?reproduction?in?any?medium,?provided?the?original?author?and?source? are ?credited? ? Abstract: ? Deposition? and? mobilization? of? fat? in? an? organism? are ? tightly? controlled? by? multiple? levels? of? endocrine? and neuroendocrine ?regulation.?Because?these?hormonal?mechanisms?ultimately?act?by?affecting?biochemical?reactions?of?fat synthesis ?or?