1 case of edaravone injection caused severe liver damage Nursing_0.docVIP

 PAGE \* MERGEFORMAT 6 1 case of edaravone injection caused severe liver damage Nursing [Keywords:] liver damage; edaravone; Care Edaravone injection is a brain protective agent, commonly used in clinical improvement of neurological symptoms caused by acute cerebral infarction, activities of daily living and functional disability. Serious adverse reactions are acute renal failure. Edaravone injection liquid cause serious liver damage, are rare, but liver and kidney function in elderly patients gradually weakened due, the condition is more serious. I department in January 2010 encounter in the course of treatment in 1 case, after active treatment, her condition improved after intensive care discharged. About 1 case Male patient, aged 81, due to dizziness, high blood pressure with lower limb difficulties in walking and hospitalization. According to patient history, physical examination and CT examination results, admission diagnosis: lacunar infarction, cerebral infarction sequela, coronary heart disease. Hospitalized check blood, liver and kidney function, electrolytes were normal, thanks to aspirin given orally 100mg 1 / day, clopidogrel tablets 75mg 1 times / day, citicoline sodium tablets 200mg 3 / day, isosorbide mononitrate acetate tablets 60mg 1 times / day, intravenous infusion of edaravone injection 30mg + 0.9% sodium chloride injection 250ml, prepared 14 days of treatment, medication 3 days back there were a few scattered rash, were not processed in 9th day infusion in patients with v. fatigue, anorexia, check liver function showed: total bilirubin 32.8umol / L, direct bilirubin 19.9umol / L, indirect bilirubin 12.9umol / L, alanine aminotransferase 687IU / L, aspartate aminotransferase 476IU / L, GT GGT 81.2IU / L, alkaline phosphatase 53IU / L, suggest liver damage. thanks for long-term use in patients with previous aspirin, clopidogrel tablets, citicoline film and isosorbide mononitrate sustained release tablets, consider arguments edarav