13 cases clinical analysis of acute mixed-lineage leukemia.docVIP

 PAGE \* MERGEFORMAT 16 13 cases clinical analysis of acute mixed-lineage leukemia Author: Tan Ye-Hui, Wang Nan Ya, Lin Du, Chun-Rong Zheng, high-Su-Jun, Li Wei 【Abstract】 Objective: To investigate the acute mixed-lineage leukemia (HAL) of the clinical characteristics. Methods: MICM classification method, of 143 cases of acute leukemia patients screened 13 cases of mixed-lineage leukemia comprehensive analysis of clinical features. Results: Acute mixed-lineage leukemia diagnosed over the same period about 9.1% of acute leukemia in 13 patients, B  Ly / My biphenotypic 9 cases, T  Ly / My biphenotypic two cases, TB  Ly / My Double Table type 2 cases of newly diagnosed increased significantly when the white blood cell count more than an average of 84.15 × 109 / L. Treatment of 12 patients, the first time, chemotherapy, up to CR 1 Li, PR 1 cases, 2 deaths; I 8 cases and 2 cases to continue treatment, are conducted the first course of treatment but not 2,3-ease. Conclusions: HAL is a special type of leukemia, the diagnosis depends on cell morphology and immunophenotype of the comprehensive evaluation. The overall poor prognosis, tumor burden, immunophenotype, cytogenetics and molecular biology are the factors that affect the prognosis. There is no clear response rate higher chemotherapy. Keywords: acute mixed-lineage leukemia; Immunophenotyping; bone marrow morphology; Cytochemistry Acute mixed-lineage leukemia (HAL) is based on the cell morphology in recent years combined with immunophenotype, molecular biology, genetics technology, and gradually be recognized and is established as a rare type of leukemia [1]. It is characterized by acute myeloid leukemia and lymphoid cells at the same time involved with lymphoid and myeloid cells, a dual character. Reports indicate that, in theory, HAL can be further divided into two pairs of table type, double-series-and double-clone type (including the series of conversion-type), the main differenc