13 Rabbit anti-human thymocyte immunoglobulin in renal transplant patients application experience.docVIP

 PAGE \* MERGEFORMAT 10 13 Rabbit anti-human thymocyte immunoglobulin in renal transplant patients application experience Of: Zhaixiu Yu Ling Dicheng Wei Wang Weigang Sun [Keywords:] kidney transplantation, rabbit anti-human thymocyte immunoglobulin, application Rabbit anti-human thymocyte immunoglobulin (ATG) is a selective immunosuppressive agent, a major role in T lymphocytes, leading to cell failure, resulting in immune suppression (1,2), can prevent and reverse most of the early rejection. immediately after renal transplantation can significantly reduce the prophylactic use of ATG of early acute rejection after surgery. I applied ATG Division renal transplant patients to prevent and treat early rejection, no 1 patient because of serious adverse reactions and stopped medicine, renal function after the application. 1 Clinical data 1.1 General Information 1 October 2009, the Centre application of ATG treated 31 patients with renal transplant, 21 males and 10 females, aged 45 to 60 years, mean age 55.1 years, mean hospitalization 13.5 d. before transplantation with ATG induction 28 cases, 3 cases of drug treatment of rejection, with an average follow-up of 6.5 months, 31 patients were stable renal function. 1.2 ATG use 1.2.1 drug induced Day of transplantation administered 4 h before surgery, usually a dose of 1 ~ 1.5 mg kg-1 d-1, adding 0.9% sodium chloride 500 ml 6 ~ 8 h pump. Infusions before and after dexamethasone 5 mg intravenous infusion given before intramuscular injection of promethazine hydrochloride 25 mg prevention of adverse reactions during the continuous application of 3 d. immunosuppressant drugs reduce it, after stopping the gradual resumption of normal dose. 1.2.2 rejection drug therapy Based on the clinical manifestations and pathological diagnosis of renal biopsy renal rejection. Mild rejection reaction induced by drug treatment with moderate or severe rejection was generally dose 1.5 mg kg-1 d-1, a cont