2 and matrix metalloproteinase inhibitor TIMP2 expression in human gliomas and its significance.docVIP

 PAGE \* MERGEFORMAT 12 2 and matrix metalloproteinase inhibitor TIMP2 expression in human gliomas and its significance Of: Zhou Ren, Bo Luning, Wang wisdom, Zhang Longzhou, including the new kit, Cao Jie [Abstract] Objective To study matrix metalloproteinase 2 (MMP 2) and their inhibitors TIMP 2 expression and glioma malignancy relationship. Immunohistochemical SP method detected 67 patients and compared the different levels glioma tissue and 10 cases of normal brain tissue MMP 2 and TIMP 2 protein expression. Results With the increase in malignant tumors, MMP 2 and TIMP 2 protein expression increased protein expression decreased. Conclusion MMP 2 and TIMP 2 the rubber qualitative assessment of tumor malignancy has important significance. [Keywords:] matrix metalloproteinase, matrix metalloproteinase inhibitor, glioma ABSTRACT: Objective To explore the expression of matrix metalloproteinase 2 (MMP 2) and its inhibitor tissue inhibitor of metalloproteinase 2 (TIMP 2) and their relation with glioma of different malignancy degree. Methods Immunohistochemical SP method was employed to examine the level of MMP 2 and TIMP 2 in surgical samples from 67 patients suffering from gliomas and 10 patients with cerebral trauma. Results As the tumor s malignancy degree increased, the expression of MMP 2 increased but the expression of TIMP 2 decreased as the tumor malignancy degree increased. Conclusion MMP 2 and TIMP 2 have a great significance in evaluating the malignancy degree of human gliomas. KEY WORDS: matrix metalloproteinases 2 (MMP 2); tissue inhibitor of metalloproteinase 2 (TIMP 2); glioma Human brain is a common malignancy of human health hazards, accounting for 40% -50 intracranial tumors%. At present, surgical treatment combined with radiotherapy and chemotherapy combined treatment overall poor efficacy, while the cause of the An important reason is the phenomenon that has the invasive growth of glioma characteristics [1]. Currently, that