2 mitochondrial antibody in primary biliary cirrhosis diagnosis.docVIP

 PAGE \* MERGEFORMAT 5 2 mitochondrial antibody in primary biliary cirrhosis diagnosis [Keywords:] primary biliary cirrhosis; GGT; ALP; AMA-M2 Primary biliary cirrhosis (primary biliary cirrhosis, PBC) is an autoimmune chronic cholestatic liver disease, onset occult, clinical manifestations are not typical, is often misdiagnosed as viral hepatitis. This article in 30 cases of primary Recurrent biliary cirrhosis clinical data are summarized below. 1 Clinical data 1.1 General information with complete data in our hospital with primary biliary cirrhosis and 30 patients with diagnosis based on the diagnosis of the American Liver Association and the International autoimmune hepatitis group (IAIHG) revised scoring criteria [1]. In which men 4 cases, 26 females, male to female ratio was 1:6. 5; aged 23 to 65 years (mean 44.1 + -6. 5) years. The main clinical manifestations were fatigue (87.5%), abdominal discomfort (78.1%), jaundice (63.8%), pruritus (59.4%) and other non-specific symptoms. hepatomegaly in 12 cases, splenomegaly in 6 cases. From the first visit to confirm the diagnosis time is 1 ~ 273 months, an average of 24.21 months. 1.2 OUTCOME MEASURES 1. 2.1 Biochemical serum biochemical testing by Japan’s Olympus AU400 automatic biochemical analyzer: total bilirubin (TBil), bilirubin (CBil), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), -glutamyl transferase (GGT) and high density lipoprotein cholesterol (HDL-C). reagents provided by the United States and Hong Wuxi. 1.2. 2 IR indexes using indirect immunofluorescence assay kit determination of autoantibodies, determined by Western blot kit type 2 mitochondrial antibody (AMA-M2) subtype, and serum IgA, IgG, IgM, etc.; serum virology Index by enzyme-linked immunosorbent assay (ELISA) method of detection. The First Affiliated Hospital of Zhongshan Medical University are completed. 1.3 Counting statistical data to describe the percentage of mea