2 Menadiol sodium phosphate Salmonella typhimurium mutagenicity studies.docVIP

 PAGE \* MERGEFORMAT 6 2 Menadiol sodium phosphate Salmonella typhimurium mutagenicity studies Author: Cui Chun, Shi Shimizu, Wang Dai Di [Abstract ] Purpose Observed Menadiol two mutagenic effects of sodium phosphate. Methods Salmonella typhimurium reverse mutation assay study Menadiol two mutagenic effect of sodium phosphate, test selection TA97, TA98, TA100, TA102 strain. Results When the two Menadiol sodium phosphate concentration in the 0.5,5,50,500,5000 μ g / III, either with or without S9 mixture of its four Salmonella strains of the role of reverse mutation were negative. Conclusion 2 Menadiol sodium phosphate prokaryotic cells in vitro without mutagenesis. [Keywords:] Menadiol two phosphate sodium; mutagenicity; Ames test [Abstract] Objective To observe the effect of menadiol sodium diphosphate induced mutation. Methods The Salmonella typhimurium reverse mutation assay was used to study menadiol sodium diphosphate induced mutation.The strains of TA97, TA98, TA100, TA102 were used in this experiment.Results When menadiol sodium diphosphate levels were at 0.1,1,10,100,1000 g per plate, It has no reverse mutation effect on the four strains of Salmonella whether the S9 mixture was addde or not. Conclusion The results of the experiment show that menadiol sodium diphosphate has no mutation effects on the procaryotic cell in vitro. [Keywords:] menadiol sodium diphosphate; mutation; Aames test Menadiol two phosphate sodium (menadiol sodium diphosphate, 1) is a water-soluble derivative of vitamin K3, the chemical known as 2 - methyl-1,4 - naphthalenediol 2 4 sodium phosphate hexahydrate. Clinic for a variety of reasons to stop bleeding caused by bleeding, but also used as a photosensitizer to treat malignant tumors. The water-soluble compound is good, easy-to made of a variety of dosage forms [1]. Major research in this study Menadiol sodium phosphate existence of two gene mutation caused by the genetic toxicity of safety data for clinical applications