2,9 Matrix metalloproteinase gene polymorphisms and premature coronary heart disease genetic susceptibility.docVIP

 PAGE \* MERGEFORMAT 28 2,9 Matrix metalloproteinase gene polymorphisms and premature coronary heart disease genetic susceptibility Of: Zhang Yan, Wang Congxia, DONG, Zhu war, Section Zong, the party Yin Hu, WEI Jin, ORIENTED Liyong Qin, Zhang Rong [Abstract] Objective To investigate the Chinese Han population in Shaanxi matrix metalloproteinase 2 (matrix metalloproteinase 2, MMP 2) gene rs2285053 and matrix metalloproteinase 9 (MMP 9) gene rs3918242 single nucleotide polymorphism and premature coronary heart disease (premature coronary artery disease, PCAD) associated disease. Methods Polymerase chain reaction-restriction fragment length polymorphism method to detect 92 cases of PCAD patients (PCAD group) and 95 age-and sex-matched non-coronary heart disease (control group ) and rs2285053 (-735C / T), rs3918242 (-1562C / T) gene single nucleotide polymorphisms, and to determine their genotype and allele statistical frequency of each genotype. ELISA assay of plasma MMP 9 level. Results MMP 2 rs2285053 polymorphism in the PCAD group and control group genotype distribution and allele frequency difference was not statistically significant (2 = 1.33, P = 0.249). MMP 9 rs3918242 sites PCAD group C / T + T / T type control group (2 = 6.22, P = 0.013), T allele frequency is also higher, there was significant difference (2 = 7.75, P = 0.005, OR = 2.66). early with acute coronary syndrome group (premature acute coronary syndrome, PACS) C / T + T / T type was higher compared with the early onset unstable angina was no significant difference (2 = 9.11, P = 0.003; 2 = 2.29, P = 0.13), early-onset unstable angina compared with the control group no statistically significant difference (2 = 1.3, P = 0.254). Logistic regression analysis showed that, MMP 9 rs3918242 loci carrying T allele is an independent risk factor for disease PCAD. Conclusion MMP 2 rs2285053 (-735) polymorphism may be no correlation between the incidence of PCAD, MMP 9 rs3918242 locus may be associ