3TSR inhibition of tumor angiogenesis in Progress.docVIP

 PAGE \* MERGEFORMAT 18 3TSR inhibition of tumor angiogenesis in Progress Of: Guo Qing, Jiang Hao, Shen Ming, Peng Kaigui, Geng Wang Ming, He Bin [Abstract] In recent years, the biological treatment of cancer increasingly receive attention, including one of the areas of concern is the application of inhibitors of blood vessels. Human thrombospondin -1 (tThrombospondin 1, TSP-1 type 1 repeats (three thrombospondin-1 type 1 repeats, 3TSR, TSRs in TSP-1 was purified from anti-angiogenic functional domain .3 TSR as a relatively new anti-angiogenesis factor, TSP-1 reserved angiogenesis inhibiting the function of , while TSP-1 largely reduced the side effects caused by other functions. It may induce apoptosis of endothelial cells by angiogenesis inhibition. [Keywords:] angiogenesis inhibitors, 3TSR, tumor Abstract: For the past few years, anti-angiogenic factors showed potent therapeutic effect on cancer by inhibiting tumor angiogenesis and may prove to be a promising agent for clinical cancer treatment. 3TSR (three thrombospondin-1 type 1 repeats) is an anti-angiogenic domain, purified from human thrombospondin-1 (TSP-1). As a relatively new anti-angiogenic factor, 3TSR retained the function of inhibiting the angiogenesis of TSP-1, while it largely reduced the side effects caused by other functions of TSP- 1. 3TSR may inhibit angiogenesis by inducing endothelial cell apoptosis. Keywords:: angiogenesis inhibitor; 3TSR; neoplasms Human Thrombospondin -1 (TSP-1 is the anti-angiogenesis, inhibit tumor growth of the natural polymer glycoprotein trimer [1], the treatment of solid tumors have a certain role, but there are many side effects of large doses, making clinical application is limited. by the TSP-1 purified from the TSP-1 type 1 repeat (3TSR TSP-1 can play with the same anti-angiogenic functional and relatively few side effects [2-3]. 1 3TSR protein characteristics 1.1 3TSR structure 3TSR in 1993 by the Washington University School of