4 - methoxycarbonyl fentanyl derivatives Synthesis and Structure-Activity Relationship Study.docVIP

 PAGE \* MERGEFORMAT 20 4 - methoxycarbonyl fentanyl derivatives Synthesis and Structure-Activity Relationship Study [Abstract] fentanyl derivatives have a high analgesic activity, 4 - methoxycarbonyl fentanyl is one of the strongest analgesic activity of compounds, the analgesic activity of morphine 10031 times, over the past few decades, This class Synthesis, analgesic activity and structure-activity relationship study has aroused great concern, this paper, 4 - methoxycarbonyl fentanyl derivatives are reviewed. [Keywords:] medicinal chemistry; structure-activity relationship; review; 4 - methoxycarbonyl fentanyl; synthesis method; analgesic activity of Synthesis and structure-activity reactionship of 4-methoxycarbonyl fentanyl derivatives [Abstract] The fentanyl derivatives have powerful analgesic activity.The greatest compound is 4-methoxycarbonyl fentanyl and its analgesic activity is 10031 multiples (morphine = 1). In the past several decades, people have great interest in synthesis, analgesic activity and structure - activity relationship of 4-methoxycarbonyl fentanyl derivatives.In this paper, the research progress of 4-methoxycarbonyl fentanyl derivatives was summarized. [Keywords:] medicinal chemistry; SRA; review; 4-methoxycarbonyl fentanyl; synthesis; analgesic activity Janssen early 20th century, such as 60 first reported a new type of potent analgesic fentanyl [1], since that type of research and application of analgesic drugs has been a great attention. Russia, in Moscow in 2002 to rescue hostages bearing factory Palace of Culture when the use of the fentanyl class of disability potent analgesic agent. Fentanyl is a well-known high narcotic analgesics, with pain, high strength, fast-acting and short duration, and so on. Fentanyl class of compounds are specific μ -opioid receptor agonist, as early as 90 years in the 20th century, Shanghai Institute of Materia Medica Chinese Academy of Sciences of the μ -opioid receptor agonist and p