About Shichangpu nutmeg orange peel volatile oil of artemisia snow percutaneous absorption of total alkaloids.docVIP

 PAGE \* MERGEFORMAT 13 About Shichangpu nutmeg orange peel volatile oil of artemisia snow percutaneous absorption of total alkaloids Of: Baiyi Cen Li Yanjie Ma Yunshu [Abstract]: Objective To investigate the Shichangpu, nutmeg, orange peel contains volatile oil of artemisia snow percutaneous penetration of total alkaloids. Methods modified Franz diffusion cell method, the mouse skin as a penetration barrier, determined by HPLC model drug in a snow alkaloids artemisia cumulative permeation amount of pigment, and Azone as the control effects of different concentrations of Shichangpu, nutmeg, orange peel contains volatile oil of snow 3 A prime artemisia penetration effect. Results gramineus 7%, 7% and 3% Volatile Oil Azone alkaloids of snow penetration of artemisia best, permeability coefficients were 5.88,6.91,5.30,5.75, and no penetration enhancers group, to promote Infiltration times were 1.09,1.28,0.98,1.06 times. Conclusion 7% Shichangpu, 7% Volatile oil of artemisia can promote a prime snow percutaneous penetration of 5% orange peel essential oil had no significant penetration effect. [Keywords:] penetration enhancers snow volatile oil of artemisia orange peel volatile oil Volatile oils Abstract: Objective To investigate the effects of volatile oils of Rhizoma Acori Tatarinowii (RAT), Semen Myristicae (SM) and Pericarpium Citri Reticulatae (PCR) on percutaneous penetration of total alkali of Shortstalk Monkshood Root through mouse skin in vitro. Methods By using an improved Franz diffusion cells, the effects of these 3 kinds of volatile oil on the percutaneous penetration of total alkali of Shortstalk Monkshood Root were observed and compared with Azone, and the cumulative amount of Bullatine A was determined by HPLC. Results 7% (v / v) volatile oil RTA and SM, 5% (v / v) volatile oil of PCR and 3% (v / v) Azone were best concentration, the penetration coefficient were 5.88, 6.91, 5.30, 5.75, respectively. Compared with the group without penetra